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beta Adducin Rabbit pAb (bs-1114R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-1114R
英文名稱 beta Adducin Rabbit pAb
中文名稱 內收蛋白抗體
別    名 ADD 2; ADD B; ADD2; ADDB; ADDL; Adducin 2(beta); Adducin 2; Adducin like; Adducin like protein 70; Adducin2; beta adducin; Erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha; Erythrocyte adducin subunit beta; MGC3339; MGC44427; ADDB_HUMAN.  
研究領域 細胞生物  信號轉導  結合蛋白  細胞類型標志物  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Rat
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 80 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human beta Adducin protein: 401-500/725 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.

Subunit:
Heterodimer of an alpha and a beta subunit.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the aldolase class II family. Adducinbn subfamily.

SWISS:
P35612

Gene ID:
119

Database links:

Entrez Gene: 119 Human

Entrez Gene: 11519 Mouse

Entrez Gene: 24171 Rat

Omim: 102681 Human

SwissProt: P35612 Human

SwissProt: Q9QYB8 Mouse

SwissProt: Q05764 Rat

Unigene: 188528 Human

Unigene: 11353 Rat



內收蛋白(Adducin)是一種膜骨架蛋白,內收蛋白可與肌動蛋白及血影蛋白復合體結合,并且通過Ca2+和鈣調蛋白的作用影響骨架蛋白的穩定性,從而影響紅細胞的形態.
產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with beta Adducin polyclonal antibody, unconjugated (bs-1114R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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