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ARC Rabbit pAb (bs-0385R)  
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產(chǎn)品編號(hào) bs-0385R
英文名稱 ARC Rabbit pAb
中文名稱 即刻早期基因ARC抗體
別    名 ARG3.1; Arc; Arg 3.1; Activity regulated cytoskeletal associated protein; Activity regulated cytoskeletal protein; Activity-regulated cytoskeleton-associated protein; Activity regulated cytoskeletal-associated protein; ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog; Activity regulated gene 3.1 protein homolog; Arg3.1; KIAA0278; ARC_HUMAN; growth factor ARC.  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse,Rat (predicted: Human,Cow,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 45 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ARC: 101-200/396 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Activity-regulated cytoskeleton-associated protein (ARC)in the brain and learning and memory, researchers believe: ARC protein is by strengthening the function of synaptic links in order to save the memory, including learning and memory and emotion. At present, the scientists will also Activity-regulated cytoskeleton-associated protein used to take drugs addiction.

Function:
Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.

Subunit:
Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.

Subcellular Location:
Cytoplasm, cytoskeleton. Endosome. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse.

Similarity:
Belongs to the ARC/ARG3.1 family.

SWISS:
Q7LC44

Gene ID:
23237

Database links:

Entrez Gene: 23237 Human

Entrez Gene: 11838 Mouse

Entrez Gene: 54323 Rat

Omim: 605235 Human

SwissProt: Q7LC44 Human

SwissProt: Q9WV31 Mouse

SwissProt: Q63053 Rat

Unigene: 40888 Human

Unigene: 741621 Human

Unigene: 25405 Mouse

Unigene: 10086 Rat



該蛋白與大腦的學(xué)習(xí)記憶有關(guān),研究人員認(rèn)為:是ARC蛋白通過加強(qiáng)了突觸的聯(lián)系功能從而儲(chǔ)存了這些記憶,包括情感和學(xué)習(xí)記憶。
目前,科學(xué)家也將該蛋白用于吸食毒品成癮性的研究。
產(chǎn)品圖片
Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Rat Cerebrum tissue lysates Primary: Anti-ARC (bs-0385R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45 kDa Observed band size: 48 kDa
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