超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久久久亚洲国产,午夜少妇拍拍视频在线观看,99久久一区二区
首頁 > 產品中心 > 一抗 > 產品信息
Mitofusin 1 Rabbit pAb (bs-0557R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-0557R
英文名稱 Mitofusin 1 Rabbit pAb
中文名稱 線粒體融合蛋白1抗體
別    名 Mitofusin 1; Fzo homolog; MFN 1; Mitochondrial transmembrane GTPase Fzo 1; Mitochondrial transmembrane GTPase FZO 2; Mitochondrial transmembrane GTPase FZO1B; Mitofusin 1; Mitofusin1; Putative transmembrane GTPase; Transmembrane GTPase MFN1; MFN1_HUMAN; Mitofusin-1.  
Specific References  (9)     |     bs-0557R has been referenced in 9 publications.
[IF=6.792] Yang Q et al. Hexavalent chromium induces mitochondrial dynamics disorder in rat liver by inhibiting AMPK/PGC-1α signaling pathway. Environ Pollut.2020 Oct;265(Pt A):114855.  WB ;  Rat.  
[IF=6.513] Zhe Li. et al. Bisphenol A aggravate selenium deficiency-induced apoptosis via miR-215-3p/Dio1 to activate ROS/PI3K/AKT pathway in chicken arterial. J CELL PHYSIOL. 2023 Apr;:  WB ;  Chicken.  
[IF=5.895] Xixi Wang. et al. Cannabidiol Alleviates Perfluorooctanesulfonic Acid-Induced Cardiomyocyte Apoptosis by Maintaining Mitochondrial Dynamic Balance and Energy Metabolic Homeostasis. J AGR FOOD CHEM. 2023;XXXX(XXX):XXX-XXX  WB ;  Mouse,Rat.  
[IF=5.572] Chengcheng Peng. et al. Crosstalk between Mfn2-mediated mitochondria associated membranes disorder and autophagy induced by molybdenum and cadmium in sheep heart. FOOD CHEM TOXICOL. 2023 Apr;174:113660  WB ;  Sheep.  
[IF=4.527] Wang S et al. Hydrogen sulfide-induced oxidative stress leads to excessive mitochondrial fission to activate apoptosis in broiler myocardia. Ecotoxicol Environ Saf. 2019 Aug 20;183:109578.  WB ;  broiler.  
[IF=4.099] Lu Yiming. et al. Cadmium induces apoptosis of pig lymph nodes by regulating the PI3K/AKT/HIF-1α pathway. Toxicology. 2021 Mar;451:152694  WB ;  Pig.  
[IF=3.7] Ku, Tingting, et al. "PM 2.5, SO 2 and NO 2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain."Chemosphere 163 (2016): 27-34.  WB ;  Mouse.  
[IF=2.835] Yuan Zhang a et al. Electroacupuncture ameliorates endotoxin-induced acute lung injury in rabbits by regulating heme oxygenase-1 expression to improve mitochondrial dynamics. Journal of King Saud University – Science, 2019.  WB ;  Rabbit.  
[IF=1.96] Qing, Shuang-Li, et al. "The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress." Journal of Trace Elements in Medicine and Biology (2014).  IHC-P ;  Rat.  
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  細胞凋亡  新陳代謝  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse,Rabbit,Horse)
產品應用 Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 81 kDa
檢測分子量
細胞定位 細胞漿 線粒體
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Mfn 1: 651-741/741 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are homologs for the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins and are mediators of mitochondrial fusion. A GTPase domain is required for Mfn protein function but the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. They are essential for embryonic development and may play a role in the pathobiology of obesity. Although the Mfn1 and Mfn2 genes are broadly expressed, they show different levels of expression in different tissues. Two Mfn1 transcripts are elevated in heart, while Mfn2 mRNA is abundantly expressed in heart and muscle tissue but present only at low levels in many other tissues. Mfn1 localizes to mitochondria and participates in at least two different high molecular weight protein complexes in a GTP-dependent manner. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2.

Function:
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.

Subunit:
Forms homomultimers and heteromultimers with MFN2. Multimerization, which is mediated by the second coiled coil region, may play an essential role in mitochondrion fusion. Participates in a high molecular weight multiprotein complex. Interacts with VAT1.

Subcellular Location:
Cytoplasm and Mitochondrion outer membrane.

Tissue Specificity:
Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.

Post-translational modifications:
Ubiquitinated by MARCH5.

Similarity:
Belongs to the mitofusin family.

SWISS:
Q8IWA4

Gene ID:
55669

Database links:

Entrez Gene: 55669 Human

Entrez Gene: 67414 Mouse

Entrez Gene: 192647 Rat

Omim: 608506 Human

SwissProt: Q8IWA4 Human

SwissProt: Q811U4 Mouse

SwissProt: Q8R4Z9 Rat

Unigene: 478383 Human

Unigene: 290414 Mouse

Unigene: 160939 Rat



線粒體融合蛋白1具有促進線粒體融合、抑制細胞增殖、保護細胞免于凋亡等多種功能。
產品圖片
Blank control: RSC96(blue), the cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice. Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 1μg in 100 μL1X PBS containing 0.5% BSA(green).
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: chinese白浆高潮videos | 欧美国产精品一二三 | 精品欧美日韩国产日漫一区不卡 | 久久伊99综合婷婷久久伊 | 老女人性生交大片免费 | 各类熟女熟妇真实视频 | 色欲综合视频天天天 | 日本一区二区三区免费A片 欧美亚州综合 | 国产资源免费观看 | 成人精品av一区二区三区网站 | 欧美牲交作爱在线 | 免费人成网站www | 国产片XXXXA片国语对白 | 91精品久久久久久粉嫩 | 国产亚洲精品久久久美女18黄 | 性做久久久久久久久 | 特级无码毛片免费视频尤物 | 国产精品第7页 | 日本黄色免费在线观看 | BAOYU最新无码网站在线观看 | 极品久久久 | 日本一道本高清 | 久久综合中文字幕一区二区三区 | 国产精品欧美 | 女兵的真人大毛片 | 亚洲天堂成人av | 嫩B人妻精品一区二区三区 avav国产 | 情侣黄网站大全免费看 | 国产高清在线精品一区 | 精品欧美一区二区在线观看欧美熟 | 亚洲国产成人精品青青草原 | 91精品欧美一区综合在线观看 | 国产亚洲欧美另类在线第1页 | 中文字幕肉感巨大的乳专区 | 少妇搡BBBB搡BBB搡野外 | 97人伦色伦成人免费视频 | a视频在线 | 人妻引诱中文字幕 | 精品国产91亚洲一区二区三区www | 麻豆免费版 | 蜜乳av一区二区 |