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PCGF4/BMI1 Rabbit pAb (bs-2999R)  
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產品編號 bs-2999R
英文名稱 PCGF4/BMI1 Rabbit pAb
中文名稱 組蛋白相關Bmi1抗體
別    名 B lymphoma Mo MLV insertion region; Bmi 1; BMI-1; MGC12685; Murine leukemia viral(bmi 1) oncogene homolog; Oncogene BMI 1; PCGF 4; PCGF4; Polycomb complex protein BMI 1; Polycomb complex protein BMI-1; Polycomb group ring finger 4; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; RNF51; RAD18; BMI1_HUMAN.  
Specific References  (1)     |     bs-2999R has been referenced in 1 publications.
[IF=1.772] Penggang Liu. et al. Expression of tumour transcription factor GLI1 in canine mammary tumours tissue. VET MED SCI. 2022 Jun 06  WB ;  Dog.  
研究領域 腫瘤  細胞生物  信號轉導  干細胞  細胞凋亡  轉錄調節因子  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Cow,Chicken,Dog)
產品應用 WB=1:500-2000,Flow-Cyt=1ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 37 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bmi1/PCGF4: 61-160/326 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway.
Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility.

Function:
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Subcellular Location:
Nucleus. Cytoplasm.

Post-translational modifications:
Monoubiquitinated. May be polyubiquitinated; which does not lead to proteasomal degradation.

Similarity:
Contains 1 RING-type zinc finger.

SWISS:
P35226

Gene ID:
648

Database links:

Entrez Gene: 100532731 Human

Entrez Gene: 648 Human

Entrez Gene: 12151 Mouse

Entrez Gene: 307151 Rat

Omim: 164831 Human

SwissProt: P35226 Human

SwissProt: P25916 Mouse

Unigene: 380403 Human

Unigene: 289584 Mouse



產品圖片
Sample: Lane 1: Mouse NIH/3T3 cell lysates Lane 2: Human MCF-7 cell lysates Primary: Anti-PCGF4/BMI1 (bs-2999R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 37 kDa Observed band size: 44 kDa
Blank control(black line):NIH/3T3. Primary Antibody (green line): Rabbit Anti-PCGF4/BMI1 antibody (bs-2999R) Dilution:1ug/Test; Secondary Antibody(white blue line): Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Isotype control(orange line): Normal Rabbit IgG Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at -20℃, The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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