超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
中文字幕乱偷在线小说,三年成全免费高清看西瓜,青青草成人网
首頁 > 產品中心 > 一抗 > 產品信息
PCGF4/BMI1 Rabbit pAb (bs-2999R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-2999R
英文名稱 PCGF4/BMI1 Rabbit pAb
中文名稱 組蛋白相關Bmi1抗體
別    名 B lymphoma Mo MLV insertion region; Bmi 1; BMI-1; MGC12685; Murine leukemia viral(bmi 1) oncogene homolog; Oncogene BMI 1; PCGF 4; PCGF4; Polycomb complex protein BMI 1; Polycomb complex protein BMI-1; Polycomb group ring finger 4; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; RNF51; RAD18; BMI1_HUMAN.  
Specific References  (1)     |     bs-2999R has been referenced in 1 publications.
[IF=1.772] Penggang Liu. et al. Expression of tumour transcription factor GLI1 in canine mammary tumours tissue. VET MED SCI. 2022 Jun 06  WB ;  Dog.  
研究領域 腫瘤  細胞生物  信號轉導  干細胞  細胞凋亡  轉錄調節因子  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Cow,Chicken,Dog)
產品應用 WB=1:500-2000,Flow-Cyt=1ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 37 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bmi1/PCGF4: 61-160/326 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway.
Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility.

Function:
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Subcellular Location:
Nucleus. Cytoplasm.

Post-translational modifications:
Monoubiquitinated. May be polyubiquitinated; which does not lead to proteasomal degradation.

Similarity:
Contains 1 RING-type zinc finger.

SWISS:
P35226

Gene ID:
648

Database links:

Entrez Gene: 100532731 Human

Entrez Gene: 648 Human

Entrez Gene: 12151 Mouse

Entrez Gene: 307151 Rat

Omim: 164831 Human

SwissProt: P35226 Human

SwissProt: P25916 Mouse

Unigene: 380403 Human

Unigene: 289584 Mouse



產品圖片
Sample: Lane 1: Mouse NIH/3T3 cell lysates Lane 2: Human MCF-7 cell lysates Primary: Anti-PCGF4/BMI1 (bs-2999R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 37 kDa Observed band size: 44 kDa
Blank control(black line):NIH/3T3. Primary Antibody (green line): Rabbit Anti-PCGF4/BMI1 antibody (bs-2999R) Dilution:1ug/Test; Secondary Antibody(white blue line): Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Isotype control(orange line): Normal Rabbit IgG Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at -20℃, The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 视频一区二区三区免费观看 | 国产学生系列一区二区三区 | av毛片在线观看地址 | 亚洲天堂久久久 | www.亚洲.com | 日韩午夜精品免费理论片 | 一级黄色毛毛片 | 亚洲一区综合 | 大地资源影视免费观看 | 亚洲精品视频在线免费播放 | 午夜免费网站 | 欧美日韩人成视频在线播放 | 国产91影院 | 一级毛片黄| 人体内射精一区二区三区 | 看色网站| 成人.comx8| 黄色大片毛片 | 日本欧美在线视频 | 99久久精品久久 | 成人午夜视频在线观看免费 | 欧美成人二区 | 色欲综合视频天天天 | 91av国产在线视频 | 中国老太老妇xx对白 | 男人的天堂Aⅴ在线无码 | 天体野营在线 | 欧美精品一区二区免费 | 性XXXXX大片免费视频 | 夜夜摸夜夜操 | 欧洲精品成人免费视频在线观看 | 国产91精品高清一区二区三区 | 国产精品视频合集 | 国产女厕偷窥系列在线视频 | 在线A片不卡的菲菲网 | 邻居少妇张开腿让我爽了一夜 | 亚洲精品一区二区三区四区高清 | 毛片在线免费观看视频 | 亚洲美腿欧美激情另类 | 国产欧美日韩一区2区 | 五月j香国内婷婷 |