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Myogenin Rabbit pAb (bs-3550R)  
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產品編號 bs-3550R
英文名稱 Myogenin Rabbit pAb
中文名稱 肌細胞生成素抗體
別    名 MYOG_HUMAN; MYOG; BHLHC3; MYF4; Class C basic helix-loop-helix protein 3(bHLHc3); Myogenic factor 4(Myf-4); BHLHC3; MYF4; MYF 4;  
Specific References  (15)     |     bs-3550R has been referenced in 15 publications.
[IF=8.713] Zhao-Bo Luo. et al. Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis. ELIFE. 2023; 12: e81858  WB ;  Mouse.  
[IF=5.959] Wang Y et al. SPARCL1 promotes C2C12 cell differentiation via BMP7-mediated BMP/TGF-β cell signaling pathway. Cell Death Dis. 2019 Nov 7;10(11):852.  WB ;  Mouse.  
[IF=5.924] Jing Zhang. et al. LncRNA SMARCD3-OT1 Promotes Muscle Hypertrophy and Fast-Twitch Fiber Transformation via Enhancing SMARCD3X4 Expression. INT J MOL SCI. 2022 Jan;23(9):4510  WB ;  Chicken.  
[IF=5.895] Sheng-Zhong Han. et al. miR-455-3p Is Negatively Regulated by Myostatin in Skeletal Muscle and Promotes Myoblast Differentiation. J AGR FOOD CHEM. 2022;70(33):10121–10133  WB ;  Pig, Mouse.  
[IF=5.682] Yilei Li. et al. Vitellogenin 2 promotes muscle development and stimulates the browning of white fat. Aging-Us. 2021 Oct 15; 13(19): 22985–23003  WB ;  Mouse.  
[IF=4.938] Du J et al. The regulation of skeletal muscle fiber-type composition by betaine is associated with NFATc1/MyoD.J Mol Med (Berl). 2018 Jun 6.  WB&ICF ;  Mouse.  
[IF=4.56] Kuan-Xiang Sun. et al. Deletion of phosphatidylserine flippase β-subunit Tmem30a in satellite cells leads to delayed skeletal muscle regeneration. Zool Res. 2021 Sep 18; 42(5): 650–659  IF ;  mouse.  
[IF=4.534] Weng S et al. Improvement of muscular atrophy by AAV–SaCas9-mediated myostatin gene editing in aged mice. Cancer Gene Ther. 2020 Dec;27(12):960-975.  WB ;  Mouse.  
[IF=4.522] Elsaeid Elnour I et al. Bta‐miR‐885 promotes proliferation and inhibits differentiation of myoblasts by targeting MyoD1. J Cell Physiol. 2020 Jan 27.  WB ;  Bovine.  
[IF=3.905] Zhi Hu. et al. MUSTN1 is an indispensable factor in the proliferation, differentiation and apoptosis of skeletal muscle satellite cells in chicken. Exp Cell Res. 2021 Oct;407:112833  WB ;  chicken.  
[IF=3.694]  Zhao Wang . et al. Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase. Cell Adhes Migr. 2020;14(1):153-164  WB ;  Bovine.  
[IF=2.985] Qiang Gao. et al. Myogenin suppresses apoptosis induced by angiotensin II in human induced pluripotent stem cell-derived cardiomyocytes. Biochem Bioph Res Co. 2021 May;552:84  IF ;  Human.  
[IF=2.985] Genghua Chen. et al. Transcriptome profile analysis reveals KLHL30 as an essential regulator for myoblast differentiation. Biochem Bioph Res Co. 2021 Jun;559:84  WB ;  Chicken.  
[IF=1.977] Jie Li. et al. MicroRNA-127-3p regulates myoblast proliferation by targeting Sept7. Biotechnol Lett. 2020 Sep;42(9):1633-1644  WB ;  Mouse.  
[IF=1.73] Xue, Jian, et al. "miR-130b-3p/301b-3p negatively regulated Rb1cc1 expression on myogenic differentiation of chicken primary myoblasts." Biotechnology Letters (2017): 1-9.  WB ;  Chicken.  
研究領域 心血管  激酶和磷酸酶  結合蛋白  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human,Rabbit,Pig,Sheep,Cow,Dog,GuineaPig,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 25 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MYOG/Myogenin: 65-180/224 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]

Function:
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.

Subunit:
Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminus region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex.

Subcellular Location:
Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.

Post-translational modifications:
Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles.

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

SWISS:
P15173

Gene ID:
4656

Database links:

Entrez Gene: 4656 Human

Entrez Gene: 17928 Mouse

Entrez Gene: 497618 Pig

Entrez Gene: 29148 Rat

SwissProt: P15173 Human

SwissProt: P12979 Mouse

SwissProt: P49812 Pig

SwissProt: P20428 Rat



MYOG是肌肉中運載氧的蛋白質,由153個氨基酸殘基組成,一種小分子蛋白質,含有血紅素,和血紅蛋白同源,與氧的結合能力介于血紅蛋白和細胞色素氧化酶之間,可幫助肌細胞將氧轉運到線粒體。 肌細胞生成素在成肌分化過程中起著決定性的作用。在人體骨骼肌的胚胎發育過程中 ,肌細胞生成素伴隨成肌過程而呈高水平表達。MYOG主要由腎臟代謝并排泄,當心肌或橫紋肌有損傷時,肌紅蛋白便釋放入血中,血清中的肌紅蛋白即可明顯升高。
產品圖片
Sample: Lane 1: Mouse Heart tissue lysates Lane 2: Rat Heart tissue lysates Primary: Anti-Myogenin (bs-3550R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25 kDa Observed band size: 28 kDa
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