| 產(chǎn)品編號 | bs-3641R |
| 英文名稱 | SUR1 Rabbit pAb |
| 中文名稱 | 磺酰脲類藥物受體1抗體 |
| 別 名 | ABC36; Abcc8; ATP binding cassette sub family C(CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8(1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR. |
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Specific References (1) | bs-3641R has been referenced in 1 publications.
[IF=0.91] Horii K et al. ATP-dependent potassium channels contribute to motor regulation of esophageal striated muscle in rats. J Vet Med Sci. 2019 Jul 9. IHC-P ; Rat.
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| 研究領(lǐng)域 | 免疫學(xué) 細(xì)胞膜受體 藥物及化合物 糖尿病 內(nèi)分泌病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Rabbit,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 175 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SUR1: 301-400/1581 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene. Subunit: Interacts with KCNJ11. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. SWISS: Q09428 Gene ID: 6833 Database links: Entrez Gene: 6833 Human Entrez Gene: 20927 Mouse Omim: 600509 Human SwissProt: Q09428 Human Unigene: 54470 Human Unigene: 11187 Rat 胰島β細(xì)胞膜含有磺酰脲受體及與之相偶聯(lián)的ATP敏感的鉀通道Ik（ATP），以及電壓依賴性的鈣通道。當(dāng)磺酰脲類藥物與其受體相結(jié)合后，可阻滯Ik（ATP）而阻鉀外流，致使細(xì)胞膜去極化，增強(qiáng)電壓依賴性鈣通道開放，胞外鈣內(nèi)流。胞內(nèi)游離鈣濃度增加后，觸發(fā)胞吐作用及胰島素的釋放。 |
| 產(chǎn)品圖片 |
Sample:
Hippocampus (Mouse) Lysate at 40 ug
Primary: Anti-SUR1 (bs-3641R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 175 kD
Observed band size: 175 kD
Sample:
Lane 1: Cerebrum (Mouse) Lysate at 40 ug
Lane 2: Pancreas (Mouse) Lysate at 40 ug
Lane 3: Stomach (Mouse) Lysate at 40 ug
Lane 4: Cerebrum (Rat) Lysate at 40 ug
Lane 5: SH-SY5Y (Human) Cell Lysate at 30 ug
Primary: Anti-SUR1 (bs-22836R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 177 kD
Observed band size: 180 kD
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