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SLC37A4 Rabbit pAb (bs-4039R)  
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產品編號 bs-4039R
英文名稱 SLC37A4 Rabbit pAb
中文名稱 葡萄糖-6磷酸轉運蛋白抗體
別    名 G6PT2; GSD1b; GSD1c; GSD1d; TRG19; G6PT1; G6PT3; Glucose-5-phosphate transporter; Glucose-6-phosphatase, transport(glucose) protein 3 antibody; Glucose-6-phosphatase, transport(glucose-6-phosphate) protein 1; Glucose-6-phosphatase, transport(phosphate/pyrophosphate) protein 2; Glucose-6-phosphate translocase; Glucose-6-phosphate transporter 1; Microsomal glucose-6-phosphate transporter; Solute carrier family 37(glucose-6-phosphate transporter), member 4; MGC15729; PRO0685; G6PT1_HUMAN.  
研究領域 腫瘤  細胞生物  免疫學  轉錄調節因子  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Pig,Cow,Dog)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 46 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human G6PT2: 25-130/429 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 SLC37A4 transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. It forms a complex with glucose-6-phosphatase which is responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.

Function:
Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein

Tissue Specificity:
Mostly expressed in liver and kidney

DISEASE:
Defects in SLC37A4 are the cause of glycogen storage disease type 1B (GSD1B) [MIM:232220]. GSD1B is a metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. GSD1 patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. GSD1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease.
Defects in SLC37A4 are the cause of glycogen storage disease type 1C (GSD1C) [MIM:232240].
Defects in SLC37A4 are the cause of glycogen storage disease type 1D (GSD1D) [MIM:232240].

Similarity:
Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.

SWISS:
O43826

Gene ID:
2542

Database links:

Entrez Gene: 2542 Human

Entrez Gene: 14385 Mouse

Entrez Gene: 29573 Rat

Omim: 602671 Human

SwissProt: O43826 Human

Unigene: 719203 Human



產品圖片
Sample: HepG2 (Human) Cell Lysate at 30 ug Primary: Anti- SLC37A4 (bs-4039R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 46 kD Observed band size: 48 kD
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