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GARB1 Rabbit pAb (bs-3766R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-3766R
英文名稱 GARB1 Rabbit pAb
中文名稱 γ1氨基丁酸受體GABAA Rβ1抗體
別    名 GABA A Receptor beta 1; GABA(A) receptor subunit beta-1; GABA-A receptor, beta-1 polypeptide; Gabrb-1; gamma Aminobutyric Acid A Receptor beta 1; gamma Aminobutyric Acid Receptor, beta-1; gamma-aminobutyric acid(GABA) A receptor, subunit beta 1; gamma-aminobutyric acid receptor subunit beta-1; GARB1; GABRA1; AW061132; B230208N19Rik; GABA(A) receptor beta 1; GABA(A) receptor subunit beta-1; GABA-A receptor, beta-1 polypeptide; Gabrb-1; GABRB1; gamma aminobutyric acid(GABA) A receptor beta 1; gamma Aminobutyric Acid A Receptor beta 1; gamma Aminobutyric Acid Receptor, beta-1; gamma-aminobutyric acid(GABA) A receptor, subunit beta 1; gamma-aminobutyric acid receptor subunit beta-1; GARB1; GBRB1_HUMAN.  
研究領域 細胞生物  免疫學  神經生物學  信號轉導  激酶和磷酸酶  細胞膜受體  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 47 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GABA A Receptor beta 1: 351-456/456 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R©1-3, GABAA R?, GABAA R gamma, GABAA R delta 1 and GABAA R delta 2. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action.

Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit:
Binds UBQLN1. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with TRAK1.

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
GABRA1 sub-subfamily.

SWISS:
P14867

Gene ID:
2554

Database links:

Entrez Gene: 2554 Human

Entrez Gene: 14394 Mouse

Entrez Gene: 29705 Rat

Omim: 137160 Human

SwissProt: P19150 Chicken

SwissProt: P08219 Cow

SwissProt: P14867 Human

SwissProt: P62812 Mouse

SwissProt: P62813 Rat

Unigene: 175934 Human

Unigene: 439668 Mouse

Unigene: 28463 Rat



Involvement in disease: Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4). A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood. Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5) [MIM:611136]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
產品圖片
Sample: Cerebrum (Rat) Lysate at 40 ug Cerebrum (Mouse) Lysate at 40 ug Cerebellum (Rat) Lysate at 40 ug Primary: Anti- GARB1 (bs-3766R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 47 kD
Sample: brain (Mouse) Lysate at 40 ug Primary: Anti-GARB1 (bs-3766R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 47 kD
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