| 產(chǎn)品編號(hào) | bs-0467P |
| 英文名稱(chēng) | Ghrelin Antibody Blocking Peptide |
| 中文名稱(chēng) | 腦腸肽封閉多肽 |
| 別 名 | Appetite regulating hormone; Ghrelin 27; Ghrelin 28; Ghrelin/obestatin prepropeptide; GHRL; Growth hormone releasing peptide; Growth hormone secretagogue; M46 protein; Motilin related peptide; MTLRP; Obestatin; Obestatin preprohormone; PRO1066; UNQ524; GHRL_HUMAN. |
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Specific References (2) | bs-0467P has been referenced in 2 publications.
[IF=2.784] Liu et al. Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase?B. (2018) Int.J.Mol.Med. 42:3037-3047 WB&IHC ;
[IF=1.741] Yang Juesheng. et al. Protective effect of inhibiting TRPM7 expression on hypoxia post-treatment H9C2 cardiomyocytes. Clin Hemorheol Micro. 2021 Jan;77(1):91-105
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| 克 隆 號(hào) | |
| 理論分子量 | kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Lyophilized |
| 物 種 | human |
| 純化方法 | 1 |
| 活性 | Not tested |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq, Oct 2008]. Ghrelin是近年來(lái)發(fā)現(xiàn)的一種內(nèi)源性生長(zhǎng)激素促分泌劑受體的配體。 廣泛分布在人中樞神經(jīng)系統(tǒng)(下丘腦、垂體)和消化系統(tǒng)(胃、腸、胰腺),并被發(fā)現(xiàn)擁有多種生物功能,如通過(guò)下丘腦刺激食欲、增加胃酸分泌、提高胃腸蠕動(dòng)等.進(jìn)而ghrelin和GHS-R在不同器官腫瘤組織中被發(fā)現(xiàn),如垂體瘤、胃癌、腸癌、乳腺癌、甲狀腺濾泡狀癌。 研究證明ghrelin能影響不同腫瘤細(xì)胞的生長(zhǎng)與增殖.其廣泛的生物活性為今后腫瘤的診斷、治療及預(yù)后的評(píng)估提供了新的研究方向. |
