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Jagged 2 Rabbit pAb (bs-4244R)  
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產品編號 bs-4244R
英文名稱 Jagged 2 Rabbit pAb
中文名稱 Notch配體Jagged 2蛋白抗體
別    名 D12Ggc2e; HJ 2; HJ2; JAG 2; JAG2; Jagged 2 precursor; Jagged2; Syndactylism.  
Specific References  (3)     |     bs-4244R has been referenced in 3 publications.
[IF=6.291] Changjiang Liu. et al. JNK and Jag1/Notch2 co-regulate CXCL16 to facilitate cypermethrin-induced kidney damage. ECOTOX ENVIRON SAFE. 2022 Jun;238:113582  WB ;  Rat.  
[IF=5.279] Jiuyan Zhang. et al. Lycopene Alleviates Chronic Stress-Induced Spleen Apoptosis and Immunosuppression via Inhibiting the Notch Signaling Pathway in Rats. J Agr Food Chem. 2022;XXXX(XXX):XXX-XXX  WB ;  Rat.  
[IF=2.094] Yating Li. et al. Effects of Notch2 on proliferation, apoptosis and steroidogenesis in bovine luteinized granulosa cells. Theriogenology. 2021 Sep;171:55  IF,IHC ;  Cow.  
研究領域 腫瘤  免疫學  神經生物學  干細胞  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Pig,Cow,Dog)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 134 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Jagged 2: 201-300/1238 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Jagged 2 is a Notch ligand involved in the mediation of Notch signaling. Jagged 2 is expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Jagged 2 is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for Jagged 2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.

Similarity:
Contains 1 DSL domain.
Contains 16 EGF-like domains.
Contains 1 VWFC domain.

SWISS:
Q9Y219

Gene ID:
3714

Database links:

Entrez Gene: 3714 Human

Entrez Gene: 16450 Mouse

Entrez Gene: 29147 Rat

Omim: 602570 Human

SwissProt: Q9Y219 Human

SwissProt: Q9QYE5 Mouse

SwissProt: P97607 Rat

Unigene: 433445 Human

Unigene: 22459 Rat



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