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SMAD9 Rabbit pAb (bs-4253R)  
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產品編號 bs-4253R
英文名稱 SMAD9 Rabbit pAb
中文名稱 SMAD家族9抗體
別    名 AI528653; BSP 1; BSP1; DKFZp781C1895; DKFZp781O1323; Dwarfin A; Dwf A; DwfA; Dwfc; hSMAD1; hSmad5; JV 41; JV4 1; JV41; JV5 1; MAD(mothers against decapentaplegic, Drosophila) homolog 1; MAD(mothers against decapentaplegic, Drosophila) homolog 9; MAD homolog 1; MAD homolog 9; MAD homolog1(mothers against decapentaplegic, Drosophila); Mad related protein 1; MAD, mothers against decapentaplegic homolog 9; MADH 1; Madh1; MADH5; MADH6; MADH9; Madr 1; MADR1; Mlp1; Mothers against decapentaplegic, drosophila, homolog of, 9; Mothers against DPP homolog 1; Mothers against DPP homolog 9; MusMLP; OTTHUMP00000178565; OTTMUSP00000022970; OTTMUSP00000022971; OTTMUSP00000022972; OTTMUSP0000002324; OTTMUSP00000023428; Sma and Mad related protein 1; Sma-and Mad-related protein 1; SMAD; SMAD family member 5; SMAD mothers against DPP homolog 1 Drosophila; SMAD8; SMAD8A; SMAD8B; Spinal muscular atrophy distal with upper limb predominance; TGF beta signaling protein 1; Transforming growth factor beta signaling protein 1; Transforming growth factor-beta signaling protein 1.  
Specific References  (2)     |     bs-4253R has been referenced in 2 publications.
[IF=4.427] Lijie Dong. et al. RNA sequencing reveals BMP4 as a basis for the dual-target treatment of diabetic retinopathy. J Mol Med. 2021 Feb;99(2):225-240  WB,IF ;  Monkey, Rat, Human.  
[IF=3.15] Yang Zhai. et al. Construction of the optimization prognostic model based on differentially expressed immune genes of lung adenocarcinoma. Bmc Cancer. 2021 Dec;21(1):1-13  IHC ;  Human.  
研究領域 腫瘤  免疫學  染色質和核信號  信號轉導  干細胞  生長因子和激素  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Pig,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=3μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 52 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SMAD9: 361-467/467 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 SMAD9 is a member of the MAD-related family of molecules. MAD-related proteins are a recently identified family of intracellular proteins that are thought to be essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily.

Function:
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

Subunit:
Interaction with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit.

Subcellular Location:
Cytoplasm (By similarity). Nucleus (By similarity). Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).

Tissue Specificity:
Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.

Post-translational modifications:
Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.

DISEASE:
Defects in SMAD9 may be a cause of primary pulmonary hypertension (PPH1) [MIM:178600]. A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.

Similarity:
Belongs to the dwarfin/SMAD family.
Contains 1 MH1 (MAD homology 1) domain.
Contains 1 MH2 (MAD homology 2) domain.

SWISS:
O15198

Gene ID:
4093

Database links:

Entrez Gene: 4093 Human

Entrez Gene: 55994 Mouse

Entrez Gene: 85435 Rat

Omim: 603295 Human

SwissProt: O15198 Human

SwissProt: Q9JIW5 Mouse

SwissProt: O54835 Rat

Unigene: 123119 Human

Unigene: 244353 Mouse

Unigene: 10862 Rat



產品圖片
Sample: Heart (Mouse) Lysate at 40 ug Muscle (Mouse) Lysate at 40 ug Primary: Anti-SMAD9 (bs-4253R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD
Sample: Lane 1: Mouse Testis tissue lysates Lane 2: Mouse Skin tissue lysates Lane 3: Rat Testis tissue lysates Lane 4: Human HeLa cell lysates Lane 5: Human A549 cell lysates Lane 6: Human HepG2 cell lysates Primary: Anti-SMAD9 (bs-4253R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 50 kDa
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SMAD9) Polyclonal Antibody, Unconjugated (bs-4253R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Positive control: Hela cells Concebtration: 3μg/10^6 cells Incubation conditions: Avoid light , 30 minutes on the ice.
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