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TACC2 Rabbit pAb (bs-5736R)  
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產品編號 bs-5736R
英文名稱 TACC2 Rabbit pAb
中文名稱 轉化酸性卷曲含蛋白質2
別    名 TACC2_HUMAN; Anti zuai 1; AZU 1; AZU1; ECTACC; TACC 2; Transforming acidic coiled coil containing protein 2.  
研究領域 腫瘤  細胞生物  免疫學  細胞周期蛋白  細胞分化  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Cow,Dog)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 309 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TACC2: 2851-2948/2948 
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 TACC2 is a conserved family of centrosome and microtubule interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.

Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

Subunit:
Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome.

Tissue Specificity:
Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.

Post-translational modifications:
Phosphorylated by TTK; which is required for localization in centrosome.

Similarity:
Belongs to the TACC family.
Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain.

SWISS:
O95359

Gene ID:
10579

Database links:

Entrez Gene: 10579 Human

Entrez Gene: 57752 Mouse

Entrez Gene: 309025 Rat

Omim: 605302 Human

SwissProt: O95359 Human

SwissProt: Q811U0 Mouse

Unigene: 501252 Human

Unigene: 86322 Mouse

Unigene: 13989 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TACC2) Polyclonal Antibody, Unconjugated (bs-5736R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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