超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
91福利国产在线观一区二区 ,优酷tv,日韩av一二区
首頁 > 產品中心 > 一抗 > 產品信息
ADAMTS2 Rabbit pAb (bs-5858R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-5858R
英文名稱 ADAMTS2 Rabbit pAb
中文名稱 整合素樣金屬蛋白酶與凝血酶2型抗體
別    名 A disintegrin and metalloproteinase with thrombospondin motifs 2; A disintegrin like and metalloprotease(reprolysin type) with thrombospondin type 1 motif 2; ADAM metallopeptidase with thrombospondin type 1 motif 2; ADAM TS 2; ADAM TS2; ADAM-TS 2; ADAM-TS2; ADAMTS 3; ADAMTS-2; ADAMTS2; ATS2_HUMAN; EC 3.4.24.14; EDS VIIB; EDS VIIC; hPCPNI; NPI; PC I NP; PC I-NP; PCINP; PCPNI; pNPI; Procollagen I N proteinase; Procollagen I N-proteinase; Procollagen I/II amino propeptide processing enzyme; Procollagen I/II amino propeptide-processing enzyme; Procollagen N endopeptidase; Procollagen N-endopeptidase.  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉導  激酶和磷酸酶  細胞粘附分子  細胞外基質  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Pig,Cow,Chicken,Dog)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 108 kDa
檢測分子量
細胞定位 細胞外基質 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADAMTS2: 501-600/1211 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 ADAMTS2 is a member of the larger family of ADAMs (A Disintegrin And Metalloproteinase) metalloproteinases containing thrombospondin (TS) repeats. ADAMTS2 (A Disintegrin And Metalloproteinase with ThromboSpondin-2 motif), also known as Procollagen I N-Proteinase (PNP), was first described in calf skin as a proteinase that processes the amino end of Type-I collagen. PNP expression was found in skin, aorta, liver, tendon, bladder, retina, and skeletal muscle. Later, PNP was found to be a member of a larger family of ADAMs metalloproteinases containing thrombospondin (TS) repeats. Full length human ADAMTS2 contains 1211 amino acids (bovine, 1205 amino acids) and has a predicted mass of 134.7 kDa, but glycosylation and the abundance of cysteine residues gives ADAMTS2 a greater apparent molecular weight on reduced SDS-PAGE gels. Purified ADAMTS2 resolves at a lower molecular weight of 107 kDa, due to cleavage at the furin site. ADAMTS2 contains the canonical HexxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active, cleaving procollagen. In addition to the metalloprotease domain, ADAMTS2 has a propeptide domain, a prohormone convertase (PC, furin) cleavage site, a cysteine-rich domain, and three thrombospondin 1 like domains, followed by a unique C-terminal domain. ADAMTS2 does not have a transmembrane domain, unlike many of the ADAMs proteases, and is a secreted protein, much of which binds to the ECM (extracellular matrix). ADAMTS2 knockout mice develop fragile skin (similar to dermatospaxis), and male infertility. Mutations of the ADAMTS2 gene are responsible for human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis. ADAMTS2 is involved in collagen biosynthesis and may also play role in development and angiogenesis.

Function:
Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.

Subunit:
May belong to a multimeric complex. Binds specifically to collagen type XIV (By similarity).

Subcellular Location:
Secreted, extracellular space, extracellular matrix (By similarity).

Tissue Specificity:
Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.

Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity).
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).

DISEASE:
Ehlers-Danlos syndrome 7C (EDS7C) [MIM:225410]: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. Marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 1 PLAC domain.
Contains 4 TSP type-1 domains.

SWISS:
O95450

Gene ID:
9509

Database links:

Entrez Gene: 9509 Human

Entrez Gene: 216725 Mouse

Entrez Gene: 287899 Rat

Omim: 604539 Human

SwissProt: O95450 Human

SwissProt: Q5NCE0 Mouse

SwissProt: Q8C9W3 Mouse

Unigene: 23871 Human

Unigene: 591725 Human

Unigene: 110597 Mouse

Unigene: 339048 Mouse

Unigene: 86986 Rat



版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲狼人在线 | 一出一进一爽一粗一大视频免费的 | 色狠狠一区二区三区香蕉 | a级片在线免费观看视频 | 中文亏日产幕无线码一区 | 亚洲一区二区三区在线网站 | 东京热无码AV在线 | 亚洲成精品自拍 | 日韩毛片一二三区 | 麻豆bt| 在线免费小视频 | 国产精品成人自拍 | 最新韩日剧情片在线免费观看 | baoyu116.永久免费视频 | 综合久久狠狠色成人网 | 麻豆精品国产免费 | 免费级毛片 | 爱爱久久| 国产露脸无码A区久久 | 狠狠操狠狠摸 | gav成人网免费免播放器播放 | caoporn超碰最新地址进入 | 亚洲欧美成人A∨在线观看 蝌蚪成人网 | 国内免费无码自拍视频网 | 福利片网站| 无码国产精品一区二区免费虚拟VR | 日韩美女在线 | 免费黄色片子 | 欧美日韩在线亚洲二区综二 | 国产欧美综合一区二区三区 | 最新精品视频在线 | 亚洲日韩中文字幕在线播放 | 国产无套无码AⅤ在线观看 91精品国产一区二区三区在线 | 老司机午夜在线视频 | 亚洲成a人片在线不卡一二三区 | 国产成人片在线观看永久观看 | 美国一级在线观看 | 成人国产精品齐天大性 | 国产美女一级做受老师 | 亚洲午夜高清国产拍 | 久久亚洲日本 |