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CADM3 Rabbit pAb (bs-6027R)  
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產品編號 bs-6027R
英文名稱 CADM3 Rabbit pAb
中文名稱 細胞粘附分子3抗體
別    名 Brain immunoglobulin receptor; Synaptic cell adhesion molecule 3; Necl 1; synCAM3; CADM 3; Cell adhesion molecule 3; FLJ10698; IGSF4B; Immunoglobulin superfamily member 4B; NECL1; Nectin like protein 1; TSLC1 like protein 1; TSLL1; CADM3_HUMAN.  
研究領域 神經生物學  細胞粘附分子  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 41 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CADM3: 101-200/398 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Immunoglobulin superfamily member 4B (Cell adhesion molecule 3, Nectin-like protein 1) is a nectin family gene product that contains 2 Ig-like C2-type (immunoglobulin-like) domains and an Ig-like V-type (immunoglobulin-like) domain. IGSF4B is a single-pass type I membrane protein that localizes to cell-cell interacting sites along the plasma membrane. IGSF4B functions as a cell adhesion molecule at cell-cell junctions. IGSF4B can be found as a homodimer and has a dual calcium-independent adhesion function; a homophilic cell-cell interaction and a heterophilic cell-cell interaction involving IGSF4, Nectin 1 and Nectin 3. IGSF4B may also interact with EPB41L1 which has a potential for regulating structure or function of cell-cell junctions By similarity. Isoform 1 is expressed in adult and fetal brain. Isoform 2 is highly expressed in the cerebellum but is also weakly expressed in placenta. IGSF4B has been found to be markedly over-expressed in glioma cell lines and prostate cancer cell lines.

Function:
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.

Subunit:
Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK.

Subcellular Location:
Cell junction. Cell membrane. Localized at the cell-cell attached sites of the plasma membrane.

Tissue Specificity:
Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.

Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.


SWISS:
Q8N126

Gene ID:
57863

Database links:

Entrez Gene: 57863 Human

Entrez Gene: 94332 Mouse

Entrez Gene: 360882 Rat

Omim: 609743 Human

SwissProt: Q8N126 Human

SwissProt: Q99N28 Mouse

SwissProt: Q1WIM3 Rat

Unigene: 365689 Human

Unigene: 330524 Mouse

Unigene: 138884 Rat




產品圖片
Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Cerebellum tissue lysates Lane 3: Rat Cerebrum tissue lysates Lane 4: Rat Cerebellum tissue lysates Lane 5: Human SH-SY5Y cell lysates Primary: Anti-CADM3 (bs-6027R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kDa Observed band size: 45,47 kDa
Sample: Hippocampus (Mouse) Lysate at 40 ug Primary: Anti- CADM3 (bs-6027R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kD Observed band size: 48 kD
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