超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产在线日韩,一本加勒比HEZYO无码人妻,欧美色一级
首頁 > 產品中心 > 一抗 > 產品信息
Lipin 1 Rabbit pAb (bs-7533R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-7533R
英文名稱 Lipin 1 Rabbit pAb
中文名稱 磷脂酸磷酸酯酶LPIN1抗體
別    名 KIAA0188; LPIN1; PAP1; Phosphatidate phosphatase LPIN1; LPIN1_HUMAN.  
Specific References  (1)     |     bs-7533R has been referenced in 1 publications.
[IF=3.231] Pan-Pan Guo. et al. Overexpression of DGAT2 Regulates the Differentiation of Bovine Preadipocytes. ANIMALS. 2023 Jan;13(7):1195  WB ;  Bovine.  
研究領域 心血管  細胞生物  信號轉導  細胞周期蛋白  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse,Rabbit,Pig,Sheep,Cow,Dog,Goose,Chimpanzee)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 99 kDa
檢測分子量
細胞定位 細胞核 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Lipin 1: 501-600/890 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

Function:
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).

Subunit:
Interacts (via LXXIL motif) with PPARA (By similarity). Interacts with PPARGC1A (By similarity). Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription (By similarity). Interacts with MEF2C (By similarity).

Subcellular Location:
Nucleus membrane (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum membrane (By similarity).

Tissue Specificity:
Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.

Post-translational modifications:
Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex (By similarity).
Sumoylated (By similarity).

DISEASE:
Defects in LPIN1 are a cause of autosomal recessive acute recurrent myoglobinuria (ARARM) [MIM:268200]; also known as acute recurrent rhabdomyolysis. Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness and followed by excretion of myoglobin in the urine. Renal failure may occasionally occur. Onset is usually in early childhood under the age of 5 years.

Similarity:
Belongs to the lipin family.

SWISS:
Q14693

Gene ID:
23175

Database links:

Entrez Gene: 23175 Human

Entrez Gene: 14245 Mouse

Entrez Gene: 313977 Rat

Omim: 605518 Human

SwissProt: Q14693 Human

SwissProt: Q91ZP3 Mouse

Unigene: 467740 Human

Unigene: 153625 Mouse



版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 欧美日韩一区二区三区在线视频 | 国产免费又硬又黄又爽的视频喷水 | 老师掀起裙子让我把j放进去视频 | 91麻豆精品国产91久久久无需广告 | 6080亚洲精品一区二区 | 亚洲AV无码乱码在线观看看 | 中文字幕人成无码免费视频 | 夜色资源站www国产在线观看 | 成人黄色a | 香蕉久久人人爽人人爽人人片av | 97影院最新理论片 | 免费在线看一区 | FREEEⅩXX性欧美HD浪妇 | 欧美午夜激情在线 | 久久久久亚洲波多野结衣 | 韩国精品一区 | 国产路线1国产路线2022 | 无码人妻丝袜在线视频红杏 | 色七七午夜影院 | 99久久精品费精品 | 久草91视频 | 豪放女大兵在线 | 亚洲精品无码一区二区三区在线高 | 免费福利在线看 | 最新在线中文字幕 | 国产欧美在线视频 | 国内精品久久久久久久影院 | 一本久久a精品一合区久久久 | 中文字幕在线播放不卡 | 国产女做a爱免费视频 | 日韩黄色网页 | 国产美女一级做受老师 | 老黄色片| 成人午夜视频免费 | 一区二区三区国产精品 | 91精品国产爱久久丝袜脚 | 福利社午夜影院 | 国产精品igao视频网网址3d | 91精品久久久久久粉嫩 | 日本三区三区三区二区二区二区高清在线 | 久久国产精品嫩草影院的推荐理由 |