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SPECC1L Rabbit pAb (bs-7773R)  
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50ul/1180.00元
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200ul/2800.00元
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產(chǎn)品編號 bs-7773R
英文名稱 SPECC1L Rabbit pAb
中文名稱 細胞質(zhì)和紡錘體機化蛋白A抗體
別    名 Cytokinesis and spindle organization A; Cytospin-A; CYTSA; CYTSA_HUMAN; Renal carcinoma antigen NY-REN-22; SPECC1-like protein; specc1l; Sperm antigen with calponin homology and coiled-coil domains 1-like.  
研究領(lǐng)域 細胞生物  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 125 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPECC1L: 161-260/1117 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

Function:
Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.

Subunit:
May interact with both microtubules and actin cytoskeleton.

Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell junction, gap junction. Note=Colocalizes with acetylated alpha-tubulin, gamma-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center.

DISEASE:
Defects in SPECC1L are the cause of facial clefting oblique type 1 (OBLFC1) [MIM:600251]. A rare form of facial clefting. A facial cleft is any of the fissures between the embryonic prominences that normally unite to form the face.

Similarity:
Belongs to the cytospin-A family.
Contains 1 CH (calponin-homology) domain.

SWISS:
Q69YQ0

Gene ID:
23384

Database links:

Entrez Gene: 23384 Human

Entrez Gene: 74392 Mouse

SwissProt: Q69YQ0 Human

SwissProt: Q2KN98 Mouse

Unigene: 474384 Human



產(chǎn)品圖片
Sample: HL60(Human) Cell Lysate at 30 ug NIH/3T3(Mouse) Cell Lysate at 30 ug U2OS(Human) Cell Lysate at 30 ug HL60 (Human) Cell Lysate at 30 ug Primary: Anti- SPECC1L (bs-7773R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 125 kD Observed band size: 125 kD
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