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CDC123 Rabbit pAb (bs-7781R)  
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產(chǎn)品編號(hào) bs-7781R
英文名稱 CDC123 Rabbit pAb
中文名稱 細(xì)胞分裂周期蛋白CDC123抗體
別    名 C10orf7; CD123_HUMAN; CDC123; Cell division cycle protein 123 homolog; D123; HT 1080; HT-1080; Protein D123; PZ32.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  細(xì)胞周期蛋白  激酶和磷酸酶  細(xì)胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDC123/C10orf7: 101-200/336 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Required for S phase entry of the cell cycle.The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.

Function:
Required for S phase entry of the cell cycle

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.

Similarity:
Belongs to the CDC123 family.

SWISS:
O75794

Gene ID:
8872

Database links:

Entrez Gene: 8872 Human

Entrez Gene: 98828 Mouse

Entrez Gene: 116656 Rat

SwissProt: O75794 Human

SwissProt: Q8CII2 Mouse

SwissProt: Q62834 Rat

Unigene: 412842 Human

Unigene: 181490 Mouse

Unigene: 11096 Rat



產(chǎn)品圖片
Blank control: U937(fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-CDC123 antibody(bs-7781R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG (orange) ,used under the same conditions. Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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