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PAPP A2 Rabbit pAb (bs-9916R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-9916R
英文名稱 PAPP A2 Rabbit pAb
中文名稱 妊娠相關血漿蛋白A2抗體
別    名 PAPPA 2; PAPP E; PAPP-A2; PAPP-E; PAPP2_HUMAN; PAPPA 2; PAPPA2; Pappalysin 2; Pappalysin-2; PLAC3; Pregnancy associated plasma protein A2; Pregnancy associated plasma protein E1; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1.  
研究領域 心血管  細胞生物  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 173 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PAPP A2: 701-800/1791 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Pregnancy-associated plasma protein-A (Pappalysin-1 or PAPP-A), also known as Insulin-like growth factor-dependent IGF-binding protein 4 (IGFBP4) protease, is a member of the peptidase M43B family of proteins. PAPP-A, a metalloproteinase, cleaves Insulin-like growth factor binding proteins IGFBP4 and IGFBP5, releasing bound IGF. PAPP-A is primarily expressed in septa and anchoring villi in placenta and is also expressed in pregnancy serum. Levels of PAPP-A increase throughout pregnancy. Lower levels of expression can be detected in kidney, prostate, breast, ovary and endometrial tissues. PAPP-A is a secreted protein that can form homodimers; in pregnancy serum PAPP-A may also form a heterotetramer with PRG-2.

Function:
Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.

Subunit:
Monomer.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.

Similarity:
Belongs to the peptidase M43B family.
Contains 5 Sushi (CCP/SCR) domains.

SWISS:
Q9BXP8

Gene ID:
60676

Database links:

Entrez Gene: 60676 Human

Entrez Gene: 23850 Mouse

Entrez Gene: 364027 Rat

SwissProt: Q9BXP8 Human

Unigene: 187284 Human

Unigene: 458621 Mouse



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