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LSAMP Rabbit pAb (bs-11091R)  
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50ul/1180.00元
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200ul/2800.00元
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產品編號 bs-11091R
英文名稱 LSAMP Rabbit pAb
中文名稱 大腦邊緣系統(tǒng)相關膜蛋白抗體
別    名 IgLON family member 3; IGLON3; Lam; LAMP; Limbic system associated membrane protein; Limbic system associated membrane protein precursor; Limbic system-associated membrane protein; LSAMP; LSAMP_HUMAN.  
研究領域 神經生物學  細胞粘附分子  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 32 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LSAMP: 51-150/338 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 LSAMP is a neuronal surface glycoprotein found in cortical and subcortical regions of the limbic system expressed on the surface of somata and proximal dendrites of neurons. It is a member of the immunoglobulin (Ig) superfamily and belongs to the IgLON subfamily of cell adhesion molecules. LSAMP contains three Ig domains and a glycosylphosphatidylinositol anchor. It is a highly conserved protein between rodents and humans (99% sequence identity) and it is involved in the regulation of neurite outgrowth and mediation of proper circuit formation of limbic pathways. This suggests that LSAMP plays an important role in the development and function of the limbic system. In addition, LSAMP may function as a tumor suppressor in renal carcinomas.

Function:
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.

Similarity:
Belongs to the immunoglobulin superfamily. IgLON family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
Q13449

Gene ID:
4045

Database links:

Entrez Gene: 395687 Chicken

Entrez Gene: 4045 Human

Entrez Gene: 268890 Mouse

Entrez Gene: 29561 Rat

Omim: 603241 Human

SwissProt: Q98919 Chicken

SwissProt: Q13449 Human

SwissProt: Q8BLK3 Mouse

SwissProt: Q62813 Rat

Unigene: 26409 Human

Unigene: 723683 Human

Unigene: 310524 Mouse

Unigene: 396840 Mouse

Unigene: 473653 Mouse

Unigene: 10176 Rat



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