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Neprilysin 2 Rabbit pAb (bs-11102R)  
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50ul/1180.00元
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產品編號 bs-11102R
英文名稱 Neprilysin 2 Rabbit pAb
中文名稱 腦啡肽酶2抗體
別    名 Neprilysin-like Protease beta; Mel transforming oncogene like 1; Membrane metallo endopeptidase like 1; Membrane metallo endopeptidase like 2; MMEL1; Neprilysin2; Neprilysin-2; Neprilysin Like 1; MMEL2; NEPII; NL1; NL2; SEP; Soluble secreted endopeptidase.  
研究領域 神經生物學  細胞粘附分子  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Dog)
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 89 kDa
檢測分子量
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neprilysin 2: 451-550/779 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008].

Function:
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond

Subcellular Location:
Membrane; Single pass type II membrane protein. Secreted.

Tissue Specificity:
Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.

Post-translational modifications:
N-glycosylated

Similarity:
Belongs to the peptidase M13 family.

SWISS:
Q495T6

Gene ID:
79258

Database links:

Entrez Gene: 79258 Human

Entrez Gene: 27390 Mouse

Entrez Gene: 313755 Rat

SwissProt: Q495T6 Human

SwissProt: Q9ERK3 Mouse

SwissProt: P0C1T0 Rat

Unigene: 591453 Human



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