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Sidekick 1 Rabbit pAb (bs-11164R)  
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產品編號 bs-11164R
英文名稱 Sidekick 1 Rabbit pAb
中文名稱 細胞粘附分子伴侶蛋白1抗體
別    名 FLJ31425; Protein sidekick-1; sdk1; SDK1_HUMAN; sidekick 1 antibody Sidekick homolog 1, cell adhesion molecule(chicken); sidekick1.  
研究領域 細胞生物  發育生物學  神經生物學  細胞粘附分子  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 242 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sidekick 1: 1501-1600/2213 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Cell adhesion molecules influence cell growth, differentiation, embryogenesis, immune response and cancer metastasis by networking information from the extracellular matrix to the cell. Sidekick-1 (SDK1) is a 2,213 amino acid single-pass membrane protein that functions as a cell adhesion molecule by guiding axonal terminals to specific synapses in developing neurons. Existing as three alternatively spliced isoforms, Sidekick-1 is expressed in retinal neurons and contains thirteen fibronectin type-III domains and six Ig-like C2-type (immunoglobulin-like) domains. Sidekick-1 expression is upregulated in glomeruli of patients with HIV-associated nephropathy, where it leads to podocyte dysfunction. The gene encoding Sidekick-1 maps to human chromosome 7p22.2 and murine chromosome 5 G2.

Function:
Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons. Dysregulation of this protein may play an important role in podocyte dysfunction in HIV-associated nephropathy.

Subunit:
Contains 13 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Subcellular Location:
Membrane.

Tissue Specificity:
Up-regulated in glomeruli in HIV-associated nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells.

Similarity:
Contains 13 fibronectin type-III domains.
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
Q7Z5N4

Gene ID:
221935

Database links:

Entrez Gene: 221935 Human

Omim: 607216 Human

SwissProt: Q7Z5N4 Human

Unigene: 653013 Human



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