超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产免费高清,最新中文字幕在线观看视频,欧美久久一级
首頁 > 產品中心 > 一抗 > 產品信息
GRIK2 Rabbit pAb (bs-12006R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-12006R
英文名稱 GRIK2 Rabbit pAb
中文名稱 谷氨酸受體紅藻氨酸離子2/谷氨酸受體6抗體
別    名 CSNB 1B; DKFZp686H1993; EAA4; Excitatory amino acid receptor 4; G protein coupled receptor family C group 1 member F; GLR 6; GLR6; GLUR 6; GluR-6; GLUR6; Glutamate receptor 6; Glutamate receptor; Glutamate receptor ionotropic kainate 2; Gprc 1f; Gprc1f; GRIK 2; GRIK2; GRIK2 protein; GRIK2_HUMAN; GRM 6; ionotropic kainate 2.  
研究領域 細胞生物  神經生物學  信號轉導  通道蛋白  細胞膜受體  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 99 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRIK2/GLR6: 164-270/908 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem, whereas the four epsilon subunits display limited distribution.

Function:
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2.

Subunit:
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4. Interacts with NETO2 (By similarity). Interacts (via C-terminus) with KLHL17 (via kelch repeats); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expression is higher in cerebellum than in cerebral cortex.

Post-translational modifications:
Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1.
Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome.

DISEASE:
Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6) [MIM:611092]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal.

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily.

SWISS:
Q13002

Gene ID:
2898

Database links:

Entrez Gene: 2898 Human

Entrez Gene: 14806 Mouse

Entrez Gene: 54257 Rat

Omim: 138244 Human

SwissProt: Q13002 Human

SwissProt: P39087 Mouse

SwissProt: P42260 Rat

Unigene: 98262 Human

Unigene: 332838 Mouse

Unigene: 87696 Rat



版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 最新在线视频 | 免费看国产黄线在线观看 | BT天堂新版中文在线 | 人人玩人人添人人澡超碰 | 佐山爱痴汉视频一区二区三区 | 日韩激情无码免费毛片 | 伊人久久天堂 | 很黄很爽的视频网站 | 精品欧美一区二区三区久久久 | 中文字幕第一页卡通动漫在线 | 在线成人国产 | 亚洲精品国偷拍自产在线观看蜜臀 | 成年人网址在线观看 | 日本四虎影院 | 国产真实野战在线视频 | 日韩在线一卡 | 亚洲天堂福利视频 | 国产亚洲影视在线视频播放 | 欧美日本成人 | 亚洲AV无码不卡私人影院 | 中文字幕AV伊人AV无码AV狼人 | 免费色播 | 亚洲精品无码不卡在线播放 | 99av成人精品国语自产拍 | 一级做a爰性色毛片免费1 | 天堂av中文字幕 | 欧美亚洲另类丝袜综合网 | 99自拍 | 99精品免费观看 | 永久不封国产av毛片 | 欧美日韩黄视频 | 国产操女人视频 | 亚洲色大成网站WWW永久男同 | 又粗又硬又黄又爽的免费视频 | 国产精品国产三级国产专播 | 在线免费观看视频a | 佐山爱国产在线一区 | 欧美乱大交xxxxx春色视频 | 中文永久有效幕中文永久 | 老熟女高潮一区二区三区 | 少妇富婆高级按摩出水高潮 |