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ASIC3 Rabbit pAb (bs-12132R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號 bs-12132R
英文名稱 ASIC3 Rabbit pAb
中文名稱 酸敏感離子通道蛋白3抗體
別    名 ASICs3; ACCN 3; ACCN3; ASIC3_HUMAN; Acid sensing ion channel 3; Acid-sensing ion channel 3; Amiloride sensitive cation channel 3; Amiloride sensitive cation channel 3 testis; Amiloride-sensitive cation channel 3; ASIC 3; ASIC3; DRASIC; hASIC 3; hASIC3; hTNaC 1; hTNaC1; Modulatory subunit of ASIC 2a; Modulatory subunit of ASIC2a; Neuronal amiloride sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Proton gated cation channel subunit; SLNAC 1; SLNAC1; Testis sodium channel 1; TNaC 1; TNaC1.  
Specific References  (1)     |     bs-12132R has been referenced in 1 publications.
[IF=4.81] Yuan Liping. et al. APETx2 regulates intestinal motility and visceral sensitivity in post-infectious irritable bowel syndrome mice through 5-HT signalling pathway. J PHARM PHARMACOL. 2023 Mar;:  WB ;  Mouse.  
研究領(lǐng)域 神經(jīng)生物學(xué)  通道蛋白  細(xì)胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) (predicted: Human,Mouse,Rat,Pig,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 59 kDa
檢測分子量
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 細(xì)胞外基質(zhì) 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ASIC3: 342-420/531 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Subunit:
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and DLG4 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ASIC2.

Subcellular Location:
Cell membrane. Cytoplasm. Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells.

Tissue Specificity:
Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.

Post-translational modifications:
Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ACCN3/ASIC3-ACCN1/ASIC2b channel, but does not activate a homomeric ACCN3 channel.

DISEASE:
Expressed in fetal tissues, expression increases in lung and kidney adult tissues.

Similarity:
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN3 subfamily.

SWISS:
Q9UHC3

Gene ID:
9311

Database links:

Entrez Gene: 9311 Human

Entrez Gene: 171209 Mouse

Entrez Gene: 286920 Rat

Omim: 611741 Human

SwissProt: Q9UHC3 Human

SwissProt: Q6X1Y6 Mouse

SwissProt: O35240 Rat

Unigene: 647113 Human

Unigene: 299636 Mouse

Unigene: 24225 Rat



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