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DLGAP1 Rabbit pAb (bs-12138R)  
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50ul/1180.00元
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產品編號 bs-12138R
英文名稱 DLGAP1 Rabbit pAb
中文名稱 PSD95結合蛋白1抗體
別    名 PSD95 binding protein 1; DAP 1 ALPHA; DAP 1; DAP 1 BETA; DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1; Discs large(Drosophila) homolog associated protein 1; Discs large homolog associated protein 1; Disks large associated protein 1; Disks large associated protein 1, alpha isoform, included; Disks large associated protein 1, beta isoform, included; Disks large-associated protein 1; DLGAP 1; Dlgap1; DLGP1_HUMAN; GKAP; GKAP/SAPAP; GKPA/SAPAP; Guanylate kinase associated protein; Guanylate kinase-associated protein; hGKAP; KIAA4162; MGC88156; mKIAA4162; PSD 95/SAP90 binding protein 1; PSD-95/SAP90-binding protein 1; SAP90/PSD 95 associated protein 1; SAP90/PSD-95-associated protein 1; SAPAP 1; SAPAP1.  
Specific References  (1)     |     bs-12138R has been referenced in 1 publications.
[IF=2.651] Zhang J et al. Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis. Lipids Health Dis. 2020 Mar 13;19(1):39  WB,IF ;  mouse.  
研究領域 細胞生物  神經生物學  信號轉導  通道蛋白  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 109 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAPAP1/DLGAP1: 241-360/977 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Members of the postsynaptic density-95 (PSD-95)/SAP90 family of membrane-associated guanylate kinase (MAGUK) proteins function as multimodular scaffolds that organize protein-signaling complexes at neuronal synapses. PSD-95/SAP90 binds guanylate kinase-associated protein (GKAP), also designated GK domain-binding protein, DAP-1-a, DAP-1-b, PSD-95 binding protein, PSD-95/SAP90 associated protein, or SAPAP, through the guanylate kinase domain. GKAP is expressed widely in neurons of the cortex and hippocampus and in the Purkinje and granule cells of the cerebellum. GKAP is localized specifically in the PSD of glutamatergic synapses, consistent with its direct interaction with PSD-95 family proteins.

Function:
Part of the postsynaptic scaffold in neuronal cells.

Subunit:
Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1 (By similarity).

Subcellular Location:
Cell membrane. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Found in postsynaptic density of neuronal cells.

Tissue Specificity:
Expressed in brain.

Similarity:
Belongs to the SAPAP family.

SWISS:
O14490

Gene ID:
9229

Database links:

Entrez Gene: 9229 Human

Entrez Gene: 224997 Mouse

Entrez Gene: 65040 Rat

Omim: 605445 Human

SwissProt: O14490 Human

SwissProt: Q9D415 Mouse

SwissProt: P97836 Rat

Unigene: 654793 Human

Unigene: 311840 Mouse

Unigene: 367369 Mouse

Unigene: 90059 Rat



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