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VNN2 Rabbit pAb (bs-12340R)  
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產品編號 bs-12340R
英文名稱 VNN2 Rabbit pAb
中文名稱 血管非炎性蛋白2抗體
別    名 FOAP 4; FOAP-4; Glycosylphosphatidyl inositol-anchored protein GPI-80; GPI 80; GPI-80; OTTHUMP00000017228; OTTHUMP00000233789; OTTHUMP00000233791; pantetheinase; Protein FOAP-4; vanin 2; Vanin-2; Vannin 2; Vascular non-inflammatory molecule 2; VNN2_HUMAN.  
研究領域 腫瘤  心血管  發育生物學  干細胞  細胞粘附分子  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 59 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human VNN2: 101-180/520 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Vanin-2 is a 520 amino acid GPI-anchor protein that belongs to the CN hydrolase family and BTD/VNN subfamily.Widely expressed with high expression in spleen and blood, vanin-2 is suggested to be involved in thymus homing of bone marrow cells, regulation of Integrin ∫2-mediated cell adhesion, and migration and motility of neutrophils. Vanin-2 exists as five alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 6q23.2.

Function:
This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.

Subcellular Location:
Cell Membrane; Lipid-anchor, GPI-anchor

Tissue Specificity:
Widely expressed with higher expression in spleen and blood.

Similarity:
Belongs to the CN hydrolase family. BTD/VNN subfamily.
Contains 1 CN hydrolase domain.

SWISS:
O95498

Gene ID:
8875

Database links:

Entrez Gene: 8875 Human

Omim: 603571 Human

SwissProt: O95498 Human

Unigene: 293130 Human



產品圖片
Sample: Lane 1: Human HeLa cell lysates Lane 2: Human K562 cell lysates Primary: Anti-VNN2 (bs-12340R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kDa Observed band size: 35 kDa
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