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5T4 Rabbit pAb (bs-12348R)  
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產品編號 bs-12348R
英文名稱 5T4 Rabbit pAb
中文名稱 滋養層細胞糖蛋白5T4抗體
別    名 5T4; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; 5T4AG; M6P1; TPBG; TPBG_HUMAN; Trophoblast glycoprotein.  
研究領域 腫瘤  細胞生物  發育生物學  干細胞  轉錄調節因子  糖蛋白  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Cow,Dog)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 43 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TPBG/5T4: 31-100/420 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 TPBG is a 420 amino acid single-pass type I membrane protein expressed by all types of trophoblasts as early as 9 weeks of development. TPBG contains an N-terminal putative signal sequence, a 310-residue extracellular region, a membrane anchorage domain and a 44-amino acid cytoplasmic tail with a potential phosphorylation site. The extracellular region has seven potential N-glycosylation sites and seven leucine-rich repeats, which are located in two regions separated by a hydrophilic stretch. Suggested to be involved in cell adhesion, TPBG may also be associated with tumor growth and progression.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Similarity:
Contains 6 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

SWISS:
Q13641

Gene ID:
7162

Database links:

Entrez Gene: 7162 Human

Entrez Gene: 21983 Mouse

Entrez Gene: 83684 Rat

Omim: 190920 Human

SwissProt: Q13641 Human

SwissProt: Q9Z0L0 Mouse

SwissProt: Q5PQV5 Rat

Unigene: 82128 Human

Unigene: 20864 Mouse

Unigene: 484180 Mouse

Unigene: 43122 Rat



產品圖片
Sample: HepG2 Cell (Human) Lysate at 30 ug A549 Cell (Human) Lysate at 30 ug Primary: Anti-5T4 (bs-12348R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 43 kD Observed band size: 63 kD
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