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phospho-alpha Adducin (Thr445) Rabbit pAb (bs-12961R)  
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50ul/1180.00元
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產品編號 bs-12961R
英文名稱 phospho-alpha Adducin (Thr445) Rabbit pAb
中文名稱 磷酸化內收蛋白抗體
別    名 Adducin(phospho T445); p-Adducin(phospho T445); ADD1; ADDA; Adducin 1(alpha); Adducin 1; alpha adducin; ADDA_HUMAN.  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  信號轉導  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 80 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human alpha Adducin around the phosphorylation site of Thr445: EK(p-T)RW 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

Subunit:
Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.

Similarity:
Belongs to the aldolase class II family. Adducin subfamily.

SWISS:
P35611

Gene ID:
118

Database links:

Entrez Gene: 118 Human

Entrez Gene: 11518 Mouse

Entrez Gene: 24170 Rat

Omim: 102680 Human

SwissProt: P35611 Human

SwissProt: Q9QYC0 Mouse

SwissProt: Q63028 Rat

Unigene: 183706 Human

Unigene: 289106 Mouse

Unigene: 5788 Rat




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