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FKBP38 Rabbit pAb (bs-13179R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-13179R
英文名稱 FKBP38 Rabbit pAb
中文名稱 肽基脯氨酸異構酶酶FKBP8抗體
別    名 38 kDa FK 506 binding protein homolog; 38 kDa FK506-binding protein; 38 kDa FKBP; 38kDa; FK506 binding protein 8; FK506 binding protein 8, 38kDa; FK506 binding protein, 38kDa; FK506-binding protein 8; FKBP 38; FKBP-38; FKBP-8; FKBP8; FKBP8_HUMAN; FKBPR38; hFKBP38; Peptidyl-prolyl cis-trans isomerase FKBP8; PPIase FKBP8; Rotamase; Sam11.  
研究領域 細胞生物  神經生物學  信號轉導  細胞凋亡  轉錄調節因子  結合蛋白  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 45 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 線粒體
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FKBP38/FKBP8: 311-412/412 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 FKBP8 is an immunophilin family member lacking PPIase/arotamase activity that influences immunoregulation, protein folding and trafficking in neurons associated with memory function. The FKBPr38 form derives from a truncated ORF. Presenilin 1 and 2 form molecular complexes with梐nd promote degradation of桭KBPr38, and Bcl-2, and sequester these proteins in ER/Golgi, thereby inhibiting FKBPr38-mediated, ?secretase-independent, mitochondrial targeting of Bcl-2. FKBP8 present in the central nervous system can antagonize hedgehog (HH) signaling, where HH is critical for patterning and growth of many tissues in the developing embryo. Mouse FKBPr38 mRNA is present in neurons and glial cells and appears more pronounced in neurons associated with the hippocampal formation in adult mouse brains.

Function:
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Subunit:
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.

Subcellular Location:
Mitochondrion membrane.

Tissue Specificity:
Widely expressed. Highest levels seen in the brain.

Similarity:
Contains 1 PPIase FKBP-type domain.
Contains 3 TPR repeats.

SWISS:
Q14318

Gene ID:
23770

Database links:

Entrez Gene: 23770 Human

Entrez Gene: 14232 Mouse

Entrez Gene: 290652 Rat

Omim: 604840 Human

SwissProt: Q14318 Human

SwissProt: O35465 Mouse

SwissProt: Q3B7U9 Rat

Unigene: 173464 Human

Unigene: 141864 Mouse

Unigene: 99789 Rat



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