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GAS2 Rabbit pAb (bs-13289R)  
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產品編號 bs-13289R
英文名稱 GAS2 Rabbit pAb
中文名稱 生長休止特定蛋白2抗體
別    名 GAS 2; GAS-2; Gas2; GAS2_HUMAN; Growth arrest specific 2; Growth arrest specific protein 2; Growth arrest-specific protein 2; MGC32610.  
研究領域 細胞生物  信號轉導  細胞凋亡  生長因子和激素  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 35 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GAS2: 141-240/313 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Gas2 is a 313 amino acid protein encoded by the human gene GAS2. Gas2 is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 and caspase-7) at Asparagine 278 during apoptosis. The cleaved form resulting from this dramatically induces the rearrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells. Gas2 is believed to also be involved in the membrane ruffling process. During the G0-G1 transition phase Gas2 can be found phosphorylated on its serine residues. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated but when hyperphosphorylated it will accumulate at membrane ruffles. Gas2 is specifically expressed at growth arrest and is ubiquitously expressed with highest levels found in liver, lung and kidney. There is no evidence, however, of Gas2 expression in spleen.

Function:
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.

Subcellular Location:
Cytoplasm > cytoskeleton. Membrane. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.

Tissue Specificity:
Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.

Post-translational modifications:
Cleaved, during apoptosis, on a specific aspartic residue by caspases.
Phosphorylated on serine residues during the G0-G1 transition phase.

Similarity:
Belongs to the GAS2 family.
Contains 1 CH (calponin-homology) domain.
Contains 1 GAR domain.

SWISS:
O43903

Gene ID:
2620

Database links:

Entrez Gene: 2620 Human

Entrez Gene: 14453 Mouse

Omim: 602835 Human

SwissProt: O43903 Human

SwissProt: P11862 Mouse

Unigene: 632151 Human

Unigene: 207360 Mouse

Unigene: 386823 Mouse

Unigene: 471773 Mouse



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