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GPCR LGR7 Rabbit pAb (bs-15368R)  
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產品編號 bs-15368R
英文名稱 GPCR LGR7 Rabbit pAb
中文名稱 G蛋白偶聯受體LGR7蛋白抗體
別    名 Gm1018; Leucine rich repeat containing G protein coupled receptor 7; LGR7; LGR7.1; LGR7.10; LGR7.2; MGC138347; MGC142177; Relaxin family peptide receptor 1; Relaxin receptor 1; Relaxin/insulin like family peptide receptor 1; RXFP 1; RXFP1; RXFP1; RXFP1_HUMAN; RXFPR1.  
Specific References  (1)     |     bs-15368R has been referenced in 1 publications.
[IF=6.208] Anqi Sun. et al. Serelaxin Alleviates Fibrosis in Thyroid-Associated Ophthalmopathy via the Notch Pathway. INT J MOL SCI. 2023 Jan;24(9):8356  IHC,IF ;  Human.  
研究領域 細胞生物  免疫學  信號轉導  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Cow,Chicken,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 87 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPCR LGR7: 301-400/757 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Function:
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.

Similarity:
Belongs to the G-protein coupled receptor 1 family.
Contains 1 LDL-receptor class A domain.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.

SWISS:
Q9HBX9

Gene ID:
59350

Database links:

Entrez Gene: 59350 Human

Entrez Gene: 381489 Mouse

Entrez Gene: 295144 Rat

Omim: 606654 Human

SwissProt: Q9HBX9 Human

SwissProt: Q6R6I7 Mouse

SwissProt: Q6R6I6 Rat

Unigene: 591686 Human

Unigene: 331086 Mouse

Unigene: 109230 Rat



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