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GPCR MRGX2 Rabbit pAb (bs-15370R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-15370R
英文名稱 GPCR MRGX2 Rabbit pAb
中文名稱 G蛋白偶聯受體MRGX2蛋白抗體
別    名 Mas-related G-protein coupled receptor member X2; MRGPRX2; MRGX2; MRGX2_HUMAN.  
研究領域 細胞生物  免疫學  神經生物學  G蛋白偶聯受體  新陳代謝  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 37 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPCR MRGX2 : 1-100/330 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGPRX2, is a 330 amino acid multi-pass membrane protein that functions as an orphan receptor and, like MRGX, is thought to be involved in the function of nociceptive neurons. Expressed in the central nervous system with highest expression in dorsal root ganglia, MRGX2 may also be involved in cortistatin function, possibly playing a role in sleep regulation and cortical function.

Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

SWISS:
Q96LB1

Gene ID:
117194

Database links:

Entrez Gene: 117194 Human

Omim: 607228 Human

SwissProt: Q96LB1 Human

Unigene: 350566 Human



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