| 產(chǎn)品編號(hào) | bs-10361P |
| 英文名稱 | Bovine Fibrinogen (from plasma) |
| 中文名稱 | 牛纖維蛋白原 |
| 別 名 | FGA; FGA protein; FGB; FGG; Fib2; Fibrin alpha chain ;Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide chain; Fibrinogen alpha chain; Fibrinogen B alpha polypeptide; Fibrinogen beta chain; Fibrinogen G alpha polypeptide; Fibrinogen gamma cha 牛血纖維蛋白原; 纖維蛋白原; 牛血漿纖維蛋白原; 纖維蛋白原 來(lái)源牛血漿; |
| 理論分子量 | 340 kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Lyophilized |
| 物 種 | Bovine |
| 序 列 | Purified native protein |
| 內(nèi)毒素 | Not analyzed |
| 活性 | Not tested |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases. CAS號(hào)：9001-32-5 分子量： α-chain 63.5 kDa; β-chain 56 kDa; γ chain 47 kDa (about 4% carbohydrate content); soluble dimer 340 kDa; MDL：MFCD00131060 級(jí)別：BR 蛋白含量：Type I-S, 65-85% protein (≥75% of protein is clottable) 來(lái)源：牛 外觀：白色粉末 用途：細(xì)胞培養(yǎng)，合適哺乳動(dòng)物。 纖維蛋白原已應(yīng)用于外科和大規(guī)模創(chuàng)傷患者的止血治療研究。這些研究表明，與使用新鮮冷凍血漿相比，纖維蛋白原在止血方面可能更為優(yōu)越。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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