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Chp2 Rabbit pAb (bs-13923R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-13923R
英文名稱 Chp2 Rabbit pAb
中文名稱 鈣調磷酸酶B相關蛋白2抗體
別    名 Calcineurin B homologous protein 2; HCA520; CHP2_HUMAN; Hepatocellular carcinoma associated antigen 520.  
研究領域 腫瘤  細胞生物  信號轉導  結合蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Rabbit)
產品應用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 22 kDa
檢測分子量
細胞定位 細胞核 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Chp2: 1-100/196 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Chp2 binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. It is expressed in malignantly transformed cells but not detected in normal tissues.

Function:
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

Subunit:
Interacts with PPP3CA. Interacts with SLC9A1/NHE1; the interaction occurs in a calcium-dependent manner.

Subcellular Location:
Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm.

Tissue Specificity:
Expressed in malignantly transformed cells butvnot detected in normal tissues.

Similarity:
Belongs to the calcineurin regulatory subunit family. CHP subfamily.
Contains 4 EF-hand domains.

SWISS:
O43745

Gene ID:
63928

Database links:

Entrez Gene: 63928 Human

Entrez Gene: 308965 Rat

SwissProt: O43745 Human

SwissProt: Q9D869 Mouse



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