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phospho-Cortactin (Tyr421) Rabbit pAb (bs-14000R)  
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50ul/1180.00元
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產品編號 bs-14000R
英文名稱 phospho-Cortactin (Tyr421) Rabbit pAb
中文名稱 磷酸化皮層肌動蛋白抗體
別    名 Cortactin(phospho Y421); p-Cortactin(phospho Y421); Amplaxin; CTTN; EMS 1; EMS1; FLJ34459; Mammary tumor and squamous cell carcinoma associated; Oncogene EMS1; p80/85 src substrate; Src substrate cortactin; SRC8_HUMAN.  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  信號轉導  細胞凋亡  激酶和磷酸酶  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Cow,Horse)
產品應用 ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 62 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Cortactin around the phosphorylation site of Tyr421: PV(p-Y)ED 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Function:
Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle. Associated with membrane ruffles and lamellipodia.

Post-translational modifications:
Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.

Similarity:
Contains 7 cortactin repeats.
Contains 1 SH3 domain.

SWISS:
Q14247

Gene ID:
2017

Database links:

Entrez Gene: 2017 Human

Entrez Gene: 13043 Mouse

Entrez Gene: 60465 Rat

GenBank: NM_138565 Human

GenBank: NM_007803 Mouse

Omim: 164765 Human

SwissProt: Q14247 Human

SwissProt: Q60598 Mouse

Unigene: 596164 Human

Unigene: 205601 Mouse

Unigene: 107869 Rat



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