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STOM Rabbit pAb (bs-10443R)  
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產品編號 bs-10443R
英文名稱 STOM Rabbit pAb
中文名稱 紅細胞膜蛋白STOM抗體
別    名 BND7; EPB7; EPB72; Erythrocyte band 7 integral membrane protein; Erythrocyte membrane protein band 7.2(stomatin); Protein 7.2b; STOM; STOM_HUMAN; Stomatin.  
研究領域 細胞生物  神經生物學  通道蛋白  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 32 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human STOM: 61-150/288 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Function:
Thought to regulate cation conductance. May regulate ACCN1 and ACCN3 gating.

Subunit:
Homooligomer containing between 9 and 12 monomers. Interacts with ASIC1, ASIC2 and ASIC3. Interacts with LANCL1.

Subcellular Location:
Cell membrane. Cell membrane. Melanosome. Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts. Concentrates preferentially in plasma membrane protrusions and in a juxta-nuclear region which may represent Golgi-derived vesicles. Colocalizes with actin. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the band 7/mec-2 family.

SWISS:
P27105

Gene ID:
2040

Database links:

Entrez Gene: 2040 Human

Entrez Gene: 13830 Mouse

Entrez Gene: 296655 Rat

Omim: 133090 Human

SwissProt: P27105 Human

SwissProt: P54116 Mouse

Unigene: 253903 Human

Unigene: 295284 Mouse

Unigene: 229238 Rat



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