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GPR183 Rabbit pAb (bs-14497R)  
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50ul/1180.00元
100ul/1980.00元
大包裝/詢價

產品編號 bs-14497R
英文名稱 GPR183 Rabbit pAb
中文名稱 G蛋白偶聯受體183抗體
別    名 ebi 2; EBI2; EBV induced G protein coupled receptor 2; EBV-induced G-protein coupled receptor 2; ebv-induced gene 2; Epstein-Barr virus-induced gene 2; Epstein Barr virus induced gene 2; epstein-barr virus induced gene 2; Epstein-Barr virus-induced G-protein coupled receptor 2; G protein-coupled receptor 183; G-protein coupled receptor 183; GP183_HUMAN; gpr183; Lymphocyte specific G protein coupled receptor.  
研究領域 細胞生物  信號轉導  細菌及病毒  G蛋白偶聯受體  G蛋白信號  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 41 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EBV Induced Gene 2: 201-300/361 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Epstein-Barr virus-induced gene 2 is a 357 amino acid multi pass membrane protein. It is expressed in B-lymphocytes and lymphoid tissues and may function in the modulation of the immune system. Out of the nine genes that are induced by the Epstein-Barr virus, Ebi2 exhibits the highest levels of up-regulation. Ebi2 is a G-protein coupled receptor that signals through the G-protein G錳. Ebi2 contains seven hydrophobic transmembrane regions and a putative N-linked glycosylation site at its extracellular N-terminus. Ebi2 is believed to be involved in regulating the effects of the Epstein-Barr virus on B-lymphocytes. In addition, Ebi2 may play a role mediating normal lymphocyte functions.

Function:
Orphan receptor that plays a central role during humoral immunity. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P32249

Gene ID:
1880

Database links:

Entrez Gene: 1880 Human

Entrez Gene: 769212 Chicken

Entrez Gene: 540287 Cow

Entrez Gene: 100050745 Horse

Entrez Gene: 100388743 Marmoset (common)

Entrez Gene: 321019 Mouse

Entrez Gene: 679975 Rat

Omim: 605741 Human

SwissProt: Q1RMI1 Cow

SwissProt: P32249 Human

SwissProt: Q3U6B2 Mouse

SwissProt: D4A7K7 Rat

Unigene: 784 Human

Unigene: 265618 Mouse

Unigene: 179130 Rat



產品圖片
Sample: Lane 1: Mouse Lymph node tissue lysates Lane 2: Mouse Spleen tissue lysates Lane 3: Mouse Lung tissue lysates Lane 4: Rat Lymph node tissue lysates Lane 5: Rat Spleen tissue lysates Lane 6: Rat Lung tissue lysates Lane 7: Human HeLa cell lysates Lane 8: Human Jurkat cell lysates Lane 9: Human Raji cell lysates Lane 10: Human K562 cell lysates Lane 11: Human A549 cell lysates Primary: Anti-GPR183 (bs-14497R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kDa Observed band size: 38 kDa
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