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EFHD2 Rabbit pAb (bs-14520R)  
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產品編號 bs-14520R
英文名稱 EFHD2 Rabbit pAb
中文名稱 EFHD2蛋白抗體
別    名 EF hand domain containing protein 2; EF hand domain family, member D2; EF-hand domain-containing protein D2; EFHD 2; EFHD2; EFHD2_HUMAN; RP3-467K16.3; Swiprosin 1; Swiprosin-1; SWS1.  
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Pig,Sheep,Cow)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 27 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EFHD2: 51-150/240 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 EFHD2 is a 240 amino acid protein that regulates spontaneous apoptosis through the regulation of Bcl-xS abundance. Localized to membrane raft, Swiprosin-1 is expressed in lymphocytes and contains two EF-hand domains. The gene encoding Swiprosin-1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Function:
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.

Subcellular Location:
Membrane raft. In immature B-cell line WEHI231.

Tissue Specificity:
Found in lymphocytes; preferentially expressed in CD8+ cells.

Similarity:
Contains 2 EF-hand domains.

SWISS:
Q96C19

Gene ID:
79180

Database links:

Entrez Gene: 79180 Human

Entrez Gene: 27984 Mouse

Entrez Gene: 298609 Rat

SwissProt: Q96C19 Human

SwissProt: Q9D8Y0 Mouse

SwissProt: Q4FZY0 Rat

Unigene: 465374 Human

Unigene: 395598 Mouse

Unigene: 92713 Rat



產品圖片
Protein:spleen(mouse) lysate at 40ug; Primary: rabbit Anti-EFHD2 (bs-14520R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000; Predicted band size: 27 kD Observed band size: 27 kD
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