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KIF16B Rabbit pAb (bs-17041R)  
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產品編號 bs-17041R
英文名稱 KIF16B Rabbit pAb
中文名稱 驅動蛋白家族成員16B抗體
別    名 Chromosome 20 open reading frame 23; Kinesin like motor protein C20orf23; SNX23; KI16B_HUMAN; Sorting nexin 23.  
研究領域 細胞生物  免疫學  信號轉導  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Sheep,Cow)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 152 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KIF16B: 1-100/1317 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 KIF16B belongs to the kinesin like protein family. It may be involved in several stages of intracellular trafficking and is a probable microtubule dependent motor protein.

Function:
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Subunit:
Interacts with RAB14 (By similarity). Interacts with PTPN21.

Subcellular Location:
Cytoplasm, cytoskeleton {ECO:0000305}. Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.

Tissue Specificity:
Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).

Post-translational modifications:
Isoform 4 is ubiquitinated at Lys-685.

Similarity:
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Contains 1 FHA domain. {ECO:0000305}.
Contains 1 kinesin motor domain.
Contains 1 PX (phox homology) domain.

SWISS:
Q96L93

Gene ID:
55614

Database links:

Entrez Gene: 55614 Human

SwissProt: Q96L93 Human

Unigene: 101774 Human



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