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ZNF366 Rabbit pAb (bs-18510R)  
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產(chǎn)品編號(hào) bs-18510R
英文名稱 ZNF366 Rabbit pAb
中文名稱 鋅指蛋白366抗體
別    名 DC-SCRIPT; DCSCRIPT; Dendritic cell specific transcript; FLJ39796; MGC99415; Zfp366; Zfp366 zinc finger protein 366; Zinc finger protein 366; ZN366_HUMAN; ZNF366.  
研究領(lǐng)域 轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Rat (predicted: Human,Mouse,Rabbit,Sheep,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 85 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZNF366: 501-600/744 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 ZNF366 is a 744 amino acid nuclear protein that contains eleven C2H2-type zinc fingers and is thought to function in transcriptional regulation. The gene encoding ZNF366 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Function:
Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.

Subunit:
Interacts with ESR1, NRIP1 and CTBP1.

Subcellular Location:
Nucleus.

Similarity:
Contains 11 C2H2-type zinc fingers.

SWISS:
Q8N895

Gene ID:
167465

Database links:

Entrez Gene: 167465 Human

Entrez Gene: 238803 Mouse

Entrez Gene: 100360041 Rat

Omim: 610159 Human

SwissProt: Q8N895 Human

Unigene: 370303 Human

Unigene: 343207 Mouse



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (rat heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ZNF366) Polyclonal Antibody, Unconjugated (bs-18510R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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