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NRXN3 Rabbit pAb (bs-20614R)  
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產品編號 bs-20614R
英文名稱 NRXN3 Rabbit pAb
中文名稱 軸突蛋白3抗體
別    名 Neurexin III-alpha; NRXN3; NRXN 3; NRXN-3; C14orf60; Neurexin 3; Neurexin3; Neurexin-3; Neurexin III; Neurexin III-alpha; Neurexin-3-alpha [Precursor]; NRX3A_HUMAN.  
研究領域 神經生物學  細胞粘附分子  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 178 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NRXN3: 28-120/1643 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]

Function:
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis.

Subunit:
The cytoplasmic C-terminal region binds to CASK. Binds to neuroligins NLGN1, NLGN2 and NLGN3.

Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).

Tissue Specificity:
Expressed in the blood vessel walls (at protein level).

Post-translational modifications:
Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides.

Similarity:
Belongs to the neurexin family.
Contains 1 laminin G-like domain.

SWISS:
Q9Y4C0

Gene ID:
9369

Database links:

Entrez Gene: 9369 Human

Entrez Gene: 18191 Mouse

Entrez Gene: 116508 Rat

Omim: 600567 Human

SwissProt: Q9HDB5 Human

SwissProt: Q9Y4C0 Human

SwissProt: Q6P9K9 Mouse

SwissProt: Q8C985 Mouse

SwissProt: Q8CCT8 Mouse

SwissProt: Q07310 Rat



產品圖片
Sample: Hela(Human) Cell Lysate at 40 ug Primary: Anti-alpha smooth muscle Actin (bs-10196R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 178 kD Observed band size: 117 kD
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