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KCNT1 Rabbit pAb (bs-20327R)  
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產(chǎn)品編號 bs-20327R
英文名稱 KCNT1 Rabbit pAb
中文名稱 鉀離子通道亞家族T成員1抗體
別    名 bA100C15.2; EIEE14; ENFL5; KCa4.1; KCNT1; KCNT1_HUMAN; Potassium channel subfamily T member 1; Potassium channel, subfamily T, member 1; SLACK.  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  通道蛋白  細(xì)胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 137 kDa
檢測分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNT1: 101-200/1230 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Function:
Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).

Subcellular Location:
Cell membrane.

Tissue Specificity:
Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.

Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity.

Similarity:
Belongs to the potassium channel family.
Calcium-activated (TC 1.A.1.3)
subfamily. KCa4.1/KCNT1 sub-subfamily.
Contains 1 RCK N-terminal domain.


SWISS:
Q5JUK3

Gene ID:
57582

Database links:

Entrez Gene: 57582 Human

Entrez Gene: 227632 Mouse

Entrez Gene: 60444 Rat

Omim: 608167 Human

SwissProt: Q5JUK3 Human

SwissProt: Q6ZPR4 Mouse

SwissProt: Q9Z258 Rat

Unigene: 104950 Human

Unigene: 119462 Mouse

Unigene: 162642 Rat



產(chǎn)品圖片
Sample: K562 Cell (human) Lysate at 40 ug Primary: Anti-KCNT1 (bs-20327R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 137 kD Observed band size: 137 kD
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