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SLC17A5 Rabbit pAb (bs-24067R)  
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產品編號 bs-24067R
英文名稱 SLC17A5 Rabbit pAb
中文名稱 溶質載體家族17成員5抗體
別    名 AST; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; ISSD; Membrane glycoprotein HP59; NSD; S17A5_MOUSE; SD; Sialic acid storage disease; Sialin; SIASD; Slc17a5; SLD; Solute carrier family 17(anion/sugar transportermember 5; Solute carrier family 17 member 5; Vesicular H(+)/Aspartate-glutamate cotransporter.  
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Rat,Rabbit,Sheep,Cow)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 56 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse SLC17A5: 201-300/495 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. [provided by RefSeq, Jul 2008]

Function:
Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.

Subcellular Location:
Cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane.

Tissue Specificity:
Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues.

DISEASE:
Salla disease
Infantile sialic acid storage disorder
Infantile sialic acid storage disorder is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.

Similarity:
Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.

SWISS:
Q8BN82

Gene ID:
235504

Database links:

Entrez Gene: 26503 Human

Entrez Gene: 235504 Mouse

Entrez Gene: 363103 Rat

Omim: 604322 Human

SwissProt: Q9NRA2 Human

SwissProt: Q8BN82 Mouse

Unigene: 597422 Human

Unigene: 46932 Mouse

Unigene: 74591 Rat



產品圖片
Sample: Embryo (Mouse) Lysate at 40 ug Primary: Anti-SLC17A5(bs-24067R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 129 kD Observed band size: 129 kD
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