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Neuroligin 1 Rabbit pAb (bs-21796R)  
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50ul/1180.00元
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產品編號 bs-21796R
英文名稱 Neuroligin 1 Rabbit pAb
中文名稱 突觸細胞粘附分子1抗體
別    名 NLG 1; KIAA1070; MGC45115; NLG1; Neuroligin-1; NLGN1; NLGN1_HUMAN.  
研究領域 免疫學  神經生物學  細胞粘附分子  細胞表面分子  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Pig,Sheep,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 87 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neuroligin 1 : 621-720/840 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Neuroligin 1 is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. In addition, the neuroligin/beta-neurexin junction may be involved in the excitatory/inhibitory specification of CNS neuron synapses. A role for Neuroligin 1 is also suggested in autism.

Function:
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Subunit : Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC.

Subunit:
Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1.

Tissue Specificity:
Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.

Similarity:
Belongs to the type-B carboxylesterase/lipase family.

SWISS:
Q8N2Q7

Gene ID:
22871

Database links:
Entrez Gene: 22871 Human

Entrez Gene: 192167 Mouse

Entrez Gene: 116647 Rat

Omim: 600568 Human

SwissProt: Q8N2Q7 Human

SwissProt: Q99K10 Mouse

SwissProt: Q62765 Rat

Unigene: 478289 Human

Unigene: 316080 Mouse

Unigene: 10173 Rat



產品圖片
Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: U251 (Human) Cell Lysate at 30 ug Lane 3: SH-SY5Y (Human) Cell Lysate at 30 ug Lane 4: Huvec (Human) Cell Lysate at 30 ug Primary: Anti-Neuroligin 1 (bs-21796R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 120 kD Observed band size: 120 kD
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