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CD9 Rabbit pAb (bs-22293R)  
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產(chǎn)品編號(hào) bs-22293R
英文名稱 CD9 Rabbit pAb
中文名稱 CD9蛋白抗體
別    名 Tetraspanin 29; 5H9; 5H9 antigen; Antigen defined by monoclonal; 602 29; Antigen defined by monoclonal; 60229; BA 2; BA2; BTCC 1; BTCC1; CD 9; CD9; CD9 antigen; CD9 antigen p24; CD9 molecule; CD9_HUMAN; Cell growth inhibiting gene 2 protein; Cell growth-inhibiting gene 2 protein; DRAP 27; DRAP27; GIG 2; GIG2; Growth inhibiting gene 2 protein; Leukocyte antigen MIC3; MIC 3; MIC3; Motility related protein; Motility-related protein; MRP 1; MRP-1; MRP1; p24; P24; p24 antigen; Tetraspanin 29; Tetraspanin-29; Tetraspanin29; Tspan 29; Tspan-29; Tspan29.  
Specific References  (1)     |     bs-22293R has been referenced in 1 publications.
[IF=2.389] Huang Weizhen. et al. LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis. ANTI-CANCER DRUG. 2022 Jul;33(6):575-586  WB ;  Human.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  細(xì)胞表面分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse (predicted: Human,Rat,Rabbit)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 25 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD9 : 61-160/228 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. It belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). It also regulates cell motility in a variety of cell lines, and appears to be an important regulator of Schwann cell behaviour in peripheral nerve.

Function:
Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.

Subunit:
Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed by a variety of hematopoietic and epithelial cells.

Post-translational modifications:
Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

SWISS:
P21926

Gene ID:
928

Database links:
Entrez Gene: 928 Human

Entrez Gene: 12527 Mouse

Entrez Gene: 24936 Rat

Omim: 143030 Human

SwissProt: P21926 Human

SwissProt: P40240 Mouse

SwissProt: P40241 Rat

Unigene: 114286 Human

Unigene: 210676 Mouse

Unigene: 404614 Mouse

Unigene: 2091 Rat



CD9是一種普遍存在于細(xì)胞膜表面屬于四跨膜超蛋白家族的細(xì)胞表面糖蛋白, 參與質(zhì)膜的融合過程,在細(xì)胞膜生物學(xué)中發(fā)揮重要作用。 近年來(lái)經(jīng)研究發(fā)現(xiàn),CD9與多種腫瘤轉(zhuǎn)移有關(guān),故稱腫瘤轉(zhuǎn)移抑制基因亦稱抗腫瘤轉(zhuǎn)移基因。是一個(gè)新的腫瘤轉(zhuǎn)移抑制基因膜運(yùn)動(dòng)相關(guān)蛋白-1(CD9/MRP-1),其分子功能還有待于進(jìn)一步研究。CD9主要在早B細(xì)胞、活化T淋巴細(xì)胞、嗜酸性粒細(xì)胞、嗜堿性粒細(xì)胞和血小板表達(dá)。
產(chǎn)品圖片
Sample: Lung (Mouse) Lysate at 40 ug Primary: Anti- CD9 (bs-22293R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25 kD Observed band size: 24 kD
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