超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
一级做人爰片全过,最近免费中文字幕MV在线视频3,欧美午夜a级限制福利片
首頁 > 產品中心 > 一抗 > 產品信息
RIM2 Rabbit pAb (bs-22118R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-22118R
英文名稱 RIM2 Rabbit pAb
中文名稱 神經元突觸膜胞外分泌調節蛋白2抗體
別    名 Non small cell lung cancer RimL3a protein; Rab3 interacting molecule 2; RAB3IP3; Regulating synaptic membrane exocytosis protein 2; Rims2; RIMS2_HUMAN.  
研究領域 細胞生物  神經生物學  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse,Pig,Sheep,Cow,Chicken,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 160 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RIM2: 391-490/1411 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Rab3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis (1-2). Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (rab3 interacting molecule), a putative effector protein for Rab3s, is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains. Rim exists as two variants, Rim1 and Rim2, produced by alternative splicing (3). Rim1 is expressed near the active zone at the synapse, where it interacts in a GTP-dependent manner with Rab3, located on synaptic vesicles (4). Therefore, Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles (5). Both Rim1 and Rim2 can bind to cAMP-GEFII, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-dependent exocytosis (3). Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells. Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, suggesting that Rim may also play a regulatory role in insulin secretion (6).

Function:
RIM2 is a rab effector involved in exocytosis. It may act as scaffold protein. It is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP dependent manner.

Subunit:
Interacts with RAB3A and RAB3B that have been activated by GTP-binding. Interacts with RAB3C, RAB3D and RAB26. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A. Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2 (By similarity).

Subcellular Location:
Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (By similarity).

Similarity:
Contains 2 C2 domains.
Contains 1 FYVE-type zinc finger.
Contains 1 PDZ (DHR) domain.
Contains 1 RabBD (Rab-binding) domain.

SWISS:
Q9UQ26

Gene ID:
9699

Database links:

Entrez Gene: 9699 Human

Entrez Gene: 116838 Mouse

Entrez Gene: 116839 Rat

Omim: 606630 Human

SwissProt: Q9UQ26 Human

SwissProt: Q9EQZ7 Mouse

SwissProt: Q9JIS1 Rat

Unigene: 655271 Human

Unigene: 735969 Human

Unigene: 309296 Mouse

Unigene: 161948 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RIM2) Polyclonal Antibody, Unconjugated (bs-22118R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产福利在线不卡 | 色吧一区 | av视在线| 看日本毛片 | 天天综合色天天综合色h | 少妇激情av一区二区 | 7777久久亚洲中文字幕 | 天天综合亚洲色在线精品 | 337P日本欧洲亚洲高清鲁鲁 | 国产偷抇久久精品 | 天天综合网久久 | 一女被二男吃奶a片免费观看 | 久久久婷 | 真人与拘做受免费视频一 | 午夜精品一区二区久久做 | 波多野结衣在线观看一区二区 | 久久网黄色 | 亚洲tv影院 | 精品国产一区二区三区av性色 | 一级片黄色毛片 | 免费看成年人视频在线 | 337P日本欧洲亚洲高清鲁鲁 | AV永久天堂一区二区三区香港 | 911精品影院在线观看 | 精品国产亚洲一区 | 青青草成人免费 | 国产精品亚洲片在线观看不卡 | 久久婷婷五月综合色99啪 | 911日本亚洲精品 | 国产精品入口免费 | 黄色网免费在线观看 | 无码人妻精品一区二秋霞影院 | 精品国产18久久久久久二百 | 高清日韩a级毛片精品 | 视频一区二区无码制服师生 | 深夜A级毛片视频免费 | 欧美日国产 | 在线观看热码亚洲av每日更新 | 亚洲婷婷一区二区三区在线观看 | 一区二区国产精品视频 | 日韩五码在线观看 |