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Rat MIP-2 ELISA Kit (bsk13015)  
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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96T/2900.00元
大包裝/詢價
產(chǎn)品編號 bsk13015
英文名稱 Rat MIP-2 ELISA Kit
中文名稱 大鼠巨噬細胞炎性蛋白2酶聯(lián)免疫試劑盒
別    名 SCYB2; GRO2; GROb; MIP-2a;   
克 隆 號
種    屬 Rat
線性范圍 15.60 - 1,000 pg/mL
應用范圍 S/P/CC
檢測限 7 pg/mL
適用樣品基質(zhì) cell culture supernates, serum, and plasma.
保存條件 Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.).
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Mouse macrophage inflammatory protein-2 (MIP-2), also known as CXCL2, was originally identified as a heparin-binding protein secreted by an LPS-stimulated mouse macrophage cell line. A cDNA clone encoding the protein was isolated from this cell line and characterized. Based on its protein and DNA sequences, mouse MIP-2 was classified as a member of the alpha (CXC) chemokine family of inflammatory and immunoregulatory cytokines).Mouse MIP-2 cDNA encodes a 100 amino acid residue precursor protein from which the amino-terminal 27 amino acid residues are cleaved to generate the mature mouse MIP-2. The protein sequence of mouse MIP-2 shows approximately 63% identity to that of mouse KC, another mouse alpha chemokine. Mouse MIP-2 is also 60% identical to human GROβ and GROγ. Based on these protein sequence similarities, it is likely that mouse KC and MIP-2 are homologs of human GROα, β and γ chemokines. Since chemokines with protein sequence homology to human IL-8 have not been identified in mice, it has been suggested that the mouse KC and MIP-2 are functional homologs of human IL-8 in mice. A putative mouse homolog of the human IL-8 receptor beta (IL-8 Rβ) has also been cloned. This receptor shows 71% identity to human IL-8 Rβ and 68% identity to human IL-8 Rα. Both mouse KC and MIP-2 bind mouse IL-8 Rβ with high affinity.Like human IL-8, mouse MIP-2 exhibits potent neutrophil chemotactic activity and may be a key mediator of neutrophil recruitment in response to tissue injury and infection. Increased MIP-2 expression has been found to be associated with neutrophil influx in various inflammatory conditions.

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