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HSL/LIPE Rabbit pAb (bs-22905R)  
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產品編號 bs-22905R
英文名稱 HSL/LIPE Rabbit pAb
中文名稱 荷爾蒙敏感脂肪酶抗體
別    名 Hormone sensitive lipase; hormone-sensitive lipase; Hormone sensitive lipase testicular isoform; HSL; LHS; Lipase hormone sensitive; LIPE; Hormone-sensitive lipase; LIPS_HUMAN.  
研究領域 心血管  免疫學  生長因子和激素  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse,Pig,Sheep,Cow)
產品應用 IHC-P=1:400-800,IHC-F=1:400-800,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 116 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HSL/LIPE : 441-540/1076 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 HSL ( hormone- sensitive lipase ) is an enzyme involved in hydrolysis of stored triglycerides and fatty acids; important for regulation of energy homeostasis. It has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.

Function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Subunit:
Interacts with PTRF in the adipocyte cytoplasm.

Subcellular Location:
Cell membrane. Membrane, caveola. Cytoplasm, cytosol.

Similarity:
Belongs to the 'GDXG' lipolytic enzyme family.

SWISS:
Q6NSL7

Gene ID:
3991

Database links:

Entrez Gene: 3991 Human

Entrez Gene: 16890 Mouse

Entrez Gene: 25330 Rat

Omim: 151750 Human

SwissProt: Q05469 Human

SwissProt: Q6NSL7 Human

SwissProt: P54310 Mouse

SwissProt: P15304 Rat

Unigene: 656980 Human

Unigene: 158548 Mouse

Unigene: 333679 Mouse

Unigene: 10566 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (rat adrenal gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HSL) Polyclonal Antibody, Unconjugated (bs-22905R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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