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RSL1D1 Rabbit pAb (bs-22952R)  
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產品編號 bs-22952R
英文名稱 RSL1D1 Rabbit pAb
中文名稱 細胞衰老抑制基因抗體
別    名 CATX 11; CATX-11; CATX11; Cellular senescence inhibited gene protein; L12; PBK1; CSIG; L12; PBK1; Protein PBK1; Ribosomal L1 domain-containing protein 1; RL1D1_HUMAN; Ribosomal L1 domain containing 1.  
研究領域 腫瘤  染色質和核信號  信號轉導  細胞周期蛋白  轉錄調節(jié)因子  細胞分化  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat
產品應用 WB=1:500-2000,IHC-P=1:400-800,IHC-F=1:400-800,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 55 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse RSL1D1: 311-410/452 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 RSL1D1, also known as CATX-11, PBK1, L12 or CSIG, is a 490 amino acid nuclear protein that belongs to the ribosomal protein L1P family. Expressed in placenta, RSL1D1 contains many phosphorylated amino acid residues and is encoded by a gene that maps to human chromosome 16p13.13. Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias.

Subcellular Location:
Nucleus, nucleolus.

Tissue Specificity:
Placenta.

Similarity:
Belongs to the ribosomal protein L1P family. Highly divergent.

Database links:

Entrez Gene: 26156 Human

SwissProt: O76021 Human

Unigene: 401842 Human




CSIG可抑制細胞衰老并延長細胞壽命 ,可能通過核糖體生物合成過程或基因轉錄調節(jié)來調控細胞衰老過程.
產品圖片
Sample: Lane 1: Heart (Rat) Lysate at 40 ug Lane 2: Heart (Mouse) Lysate at 40 ug Lane 3: Muscle (Rat) Lysate at 40 ug Lane 4: Muscle (Mouse) Lysate at 40 ug Lane 5: Placenta (Rat) Lysate at 40 ug Lane 6: Placenta (Mouse) Lysate at 40 ug Lane 7: Cerebrum (Rat) Lysate at 40 ug Lane 8: Cerebrum (Mouse) Lysate at 40 ug Lane 9: Testis (Rat) Lysate at 40 ug Lane 10: Testis (Mouse) Lysate at 40 ug Lane 11: Uterus (Rat) Lysate at 40 ug Lane 12: Uterus (Mouse) Lysate at 40 ug Primary: Anti-RSL1D1 (bs-22952R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 52 kD
Paraformaldehyde-fixed, paraffin embedded (rat uterus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RSL1D1) Polyclonal Antibody, Unconjugated (bs-22952R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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