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phospho-Girdin (Tyr1765) Recombinant Rabbit mAb (bsm-60279R)  
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產(chǎn)品編號(hào) bsm-60279R
英文名稱 phospho-Girdin (Tyr1765) Recombinant Rabbit mAb
中文名稱 磷酸化Girdin重組兔單抗
別    名 GIV(pY1765); Girdin(phospho Y1765); p-Girdin(phospho Y1765); GRDN_HUMAN; CCDC88A; APE; GRDN; KIAA1212; Akt phosphorylation enhancer(APE); Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein(GIV); Girders of actin filament; Hook-related protein 1(HkRP1);  肌動(dòng)蛋白結(jié)合蛋白Girdin;
產(chǎn)品類型 磷酸化抗體 重組兔單抗 
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞粘附分子  
抗體來源 Rabbit
克隆類型 Recombinant
克 隆 號(hào) G5F7
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:50-100,IF=1:50-100
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 206 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human APE around the phosphorylation site of Ser1765: DT(p-Y)FI 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

SWISS:
Q3V6T2

Gene ID:
55704

Database links:

Entrez Gene: 55704 Human

Entrez Gene: 108686 Mouse

Entrez Gene: 305605 Rat

SwissProt: Q3V6T2 Human

SwissProt: Q5SNZ0 Mouse



產(chǎn)品圖片
Tissue:Rat stomach Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000 Primary ab incubation condition: 1 hour at room temperature Counter stain: Hematoxylin Comment: Color brown is the positive signal for bsm-60279R
Tissue:Human breast cancer Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000 Primary ab incubation condition: 1 hour at room temperature Counter stain: Hematoxylin Comment: Color brown is the positive signal for bsm-60279R
Tissue:Rat liver Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000 Primary ab incubation condition: 1 hour at room temperature Counter stain: Hematoxylin Comment: Color brown is the positive signal for bsm-60279R
Tissue:Mouse stomach Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000 Primary ab incubation condition: 1 hour at room temperature Counter stain: Hematoxylin Comment: Color brown is the positive signal for bsm-60279R
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