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A4GALT Rabbit pAb (bs-25228R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-25228R
英文名稱 A4GALT Rabbit pAb
中文名稱 乳糖神經酰胺4-α-半乳糖基轉移酶抗體
別    名 4 N acetylglucosaminyltransferase; 4-galactosyltransferase; 4-N-acetylglucosaminyltransferase; A14GALT; A4GALT1; A4GAT_HUMAN; alpha 1 4 galactosyltransferase; alpha 1 4 N acetylglucosaminyltransferase; alpha-1; alpha-1; alpha4Gal T1; alpha4Gal-T1; CD77 synthase; GB3 synthase; Gb3S; Globotriaosylceramide synthase; Lactosylceramide 4 alpha galactosyltransferase; Lactosylceramide 4-alpha-galactosyltransferase; P blood group(P one antigen); P(k) antigen synthase; P1; P1/Pk synthase; PK; UDP galactose beta D galactosyl beta1 R 4 alpha D galactosyltransferase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase.  
研究領域 心血管  細胞生物  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Sheep,Cow,Dog)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 40 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human A4GALT: 31-130/353 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.Expression of CD77, also called Gb3, sensitizes a cell to verotoxins, causing cellular injury that can lead to disease. Therefore, the complex regulation of CD77 biosynthesis and the activity of the enzymes involved, such as CD77 synthase, can be studied by compared gene expression between toxin-sensitive and insensitive tissues and cell lines. The highest tissue expression of CD77 synthase occurs in the kidney, mesenteric lymph node, spleen, and brain. Burkitt leukemia cells express very high levels of CD77 as well as CD77 synthase, and are sensitive to verotoxin induced apoptosis. These megakaryoblasts then never mature, leading to the arrest of platelet generation in the bone marrow, which may cause thrombocytopenia, a symptom associated with various hemorrhagic conditions.

Function:
Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.

Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein (Probable).

Tissue Specificity:
Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.

Similarity:
Belongs to the glycosyltransferase 32 family.

SWISS:
Q9NPC4

Gene ID:
53947

Database links:

Entrez Gene: 53947 Human

Entrez Gene: 239559 Mouse

Entrez Gene: 63888 Rat

Omim: 607922 Human

SwissProt: Q9NPC4 Human

SwissProt: Q67BJ4 Mouse

SwissProt: Q9JI93 Rat

Unigene: 105956 Human

Unigene: 323805 Mouse

Unigene: 48584 Rat



產品圖片
Sample: Lane 1: Mouse Kidney tissue lysates Lane 2: Mouse Heart tissue lysates Lane 3: Mouse Testis tissue lysates Lane 4: Human HeLa cell lysates Primary: Anti-A4GALT (bs-25228R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 50 kDa
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